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  Cerebellum, temporal predictability and the updating of a mental model

Kotz, S. A., Stockert, A., & Schwartze, M. (2014). Cerebellum, temporal predictability and the updating of a mental model. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 369(1658): 20130403. doi:10.1098/rstb.2013.0403.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-4218-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7F5D-8
Genre: Journal Article

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 Creators:
Kotz, Sonja A.1, 2, Author              
Stockert, Anika1, 3, Author              
Schwartze, Michael1, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2School of Psychological Sciences, University of Manchester, United Kingdom, ou_persistent22              
3Language and Aphasia Laboratory, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Cerebellum; Event-related potentials; Forward model; Lesion; Prediction; Timing
 Abstract: We live in a dynamic and changing environment, which necessitates that we adapt to and efficiently respond to changes of stimulus form ('what') and stimulus occurrence ('when'). Consequently, behaviour is optimal when we can anticipate both the 'what' and 'when' dimensions of a stimulus. For example, to perceive a temporally expected stimulus, a listener needs to establish a fairly precise internal representation of its external temporal structure, a function ascribed to classical sensorimotor areas such as the cerebellum. Here we investigated how patients with cerebellar lesions and healthy matched controls exploit temporal regularity during auditory deviance processing. We expected modulations of the N2b and P3b components of the event-related potential in response to deviant tones, and also a stronger P3b response when deviant tones are embedded in temporally regular compared to irregular tone sequences. We further tested to what degree structural damage to the cerebellar temporal processing system affects the N2b and P3b responses associated with voluntary attention to change detection and the predictive adaptation of a mental model of the environment, respectively. Results revealed that healthy controls and cerebellar patients display an increased N2b response to deviant tones independent of temporal context. However, while healthy controls showed the expected enhanced P3b response to deviant tones in temporally regular sequences, the P3b response in cerebellar patients was significantly smaller in these sequences. The current data provide evidence that structural damage to the cerebellum affects the predictive adaptation to the temporal structure of events and the updating of a mental model of the environment under voluntary attention. 2014 The Author(s) Published by the Royal Society. All rights reserved.

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Language(s): eng - English
 Dates: 2014-11-102014-12-19
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1098/rstb.2013.0403
PMID: 25385781
PMC: PMC4240970
 Degree: -

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Title: Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Royal Society
Pages: - Volume / Issue: 369 (1658) Sequence Number: 20130403 Start / End Page: - Identifier: ISSN: 0962-8436
CoNE: /journals/resource/963017382021_1