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  Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism

Zannas, A. S., & Binder, E. B. (2014). Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism. GENES BRAIN AND BEHAVIOR, 13(1), 25-37. doi:10.1111/gbb.12104.

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 Creators:
Zannas, A. S.1, Author           
Binder, E. B.1, Author           
Affiliations:
1Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

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 Abstract: Psychiatric phenotypes are multifactorial and polygenic, resulting from the complex interplay of genes and environmental factors that act cumulatively throughout an organism's lifetime. Adverse life events are strong predictors of risk for a number of psychiatric disorders and a number of studies have focused on gene-environment interactions (GxEs) occurring at genetic loci involved in the stress response. Such a locus that has received increasing attention is the gene encoding FK506 binding protein 51 (FKBP5), a heat shock protein 90 cochaperone of the steroid receptor complex that among other functions regulates sensitivity of the glucocorticoid receptor. Interactions between FKBP5 gene variants and life stressors alter the risk not only for mood and anxiety disorders, but also for a number of other disease phenotypes. In this review, we will focus on molecular and system-wide mechanisms of this GxE with the aim of establishing a framework that explains GxE interactions. We will also discuss how an understanding of the biological effects of this GxE may lead to novel therapeutic approaches.

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Language(s): eng - English
 Dates: 2013-11-102014-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000329160500004
DOI: 10.1111/gbb.12104
 Degree: -

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Title: GENES BRAIN AND BEHAVIOR
Source Genre: Journal
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Publ. Info: Chichester, UK : John Wiley & Sons Ltd.
Pages: - Volume / Issue: 13 (1) Sequence Number: - Start / End Page: 25 - 37 Identifier: ISSN: 1601-1848