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  Are TMEM genes potential candidate genes for panic disorder?

Gregersen, N. O., Buttenschon, H. N., Hedemand, A., Dahl, H. A., Kristensen, A. S., Clementsen, B., et al. (2014). Are TMEM genes potential candidate genes for panic disorder? PSYCHIATRIC GENETICS, 24(1), 37-41. doi:10.1097/YPG.0000000000000022.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0026-ADAC-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0026-ADAD-2
Genre: Journal Article

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 Creators:
Gregersen, Noomi O.1, Author
Buttenschon, Henriette N.1, Author
Hedemand, Anne1, Author
Dahl, Hans A.1, Author
Kristensen, Ann S.1, Author
Clementsen, Birita1, Author
Woldbye, David P. D.1, Author
Koefoed, Pernille1, Author
Erhardt, Angelika1, Author
Erhardt, Angelika2, Author           
Kruse, Torben A.1, Author
Wang, August G.1, Author
Borglum, Anders D.1, Author
Mors, Ole1, Author
Affiliations:
1external, ou_persistent22              
2Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

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 Abstract: We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98 and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2-q12, a previously reported candidate region for PD. Three single nucleotide polymorphisms (rs887231, rs887230 and rs4795942) located upstream and within TMEM132E showed a nominal significant association with PD primarily in the Danish cohort. No nominal significant associations were observed between TMEM98 and PD. Our data indicate that TMEM132E might contribute moderately towards the risk of developing PD.

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Language(s): eng - English
 Dates: 2014-02
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000329812000006
DOI: 10.1097/YPG.0000000000000022
 Degree: -

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Title: PSYCHIATRIC GENETICS
Source Genre: Journal
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Pages: - Volume / Issue: 24 (1) Sequence Number: - Start / End Page: 37 - 41 Identifier: ISSN: 0955-8829