English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Food intake regulating hormones in adult craniopharyngioma patients

Roemmler-Zehrer, J., Geigenberger, V., Stoermann, S., Losa, M., Crippa, V., Otto, B., et al. (2014). Food intake regulating hormones in adult craniopharyngioma patients. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 170(4), 627-635. doi:10.1530/EJE-13-0832.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Roemmler-Zehrer, J.1, Author
Geigenberger, V.1, Author
Stoermann, S.1, Author
Losa, M.1, Author
Crippa, V.1, Author
Otto, B.1, Author
Bidlingmaier, M.1, Author
Dimopoulou, C.2, Author           
Stalla, G. K.2, Author           
Schopohl, J.1, Author
Affiliations:
1external, ou_persistent22              
2Dept. Clinical Research, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035296              

Content

show
hide
Free keywords: -
 Abstract: Introduction: Patients with craniopharyngioma (CP) have disturbances of the hypothalamic-pituitary axis and serious comorbidities such as obesity. We hypothesized that the secretion of hormones regulating the nutritional status is altered in adult patients with CP compared with patients with non-functioning pituitary adenoma (NFPA). Methods: We included 40 CP (50% males, mean age: 49.6 +/- 14.3 years) and 40 NFPA (72.5% males, mean age: 63.4 +/- 9.8 years) patients. We measured glucose, insulin, leptin, total ghrelin, peptide-YY (PYY) and cholecystokinin (CCK) during oral glucose tolerance test (OGTT). Fat mass ( FM) was determined by dual X-ray absorptiometry. Results: Gender distribution was not significantly different, but CP patients were significantly younger (P < 0.001). CP patients had significantly higher BMI and FM than NFPA patients ( BMI 32 +/- 8 vs 28G4 kg/ m(2), P=0.009 and FM 37 +/- 9 vs 33 +/- 9%, PZ0.02). Fasting glucose level ( 84 +/- 12 vs 78 +/- 11 mg/ dl, P=0.03), leptin (27.9 +/- 34.2 vs 11.9 +/- 11.6 upsilon g/ l, P=0.008) and leptin levels corrected for percentage FM (0.66 +/- 0.67 vs 0.32 +/- 0.25 mg/ l%, P=0.005) were significantly higher in CP than in NFPA patients, whereas ghrelin was significantly lower ( 131 +/- 129 vs 191 +/- 119 ng/l, P=0.035). Insulin, PYY and CCK did not differ significantly between groups. After glucose load, leptin decreased significantly in CP patients (P=0.019). In both groups, ghrelin decreased significantly during OGTT ( both P < 0.001). The percentage decline was significantly smaller for CP. PYYand CCK increased equally after glucose in both groups. Conclusion: Our patients with CP have more metabolic complications than our patients with NFPA. The levels of leptin and ghrelin at fasting status and after glucose seem to be altered in CP, whereas changes in insulin, PYY and CCK do not seem to be responsible for the metabolic changes in these patients.

Details

show
hide
Language(s): eng - English
 Dates: 2014-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000334351800024
DOI: 10.1530/EJE-13-0832
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: EUROPEAN JOURNAL OF ENDOCRINOLOGY
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Bioscientifica Ltd.
Pages: - Volume / Issue: 170 (4) Sequence Number: - Start / End Page: 627 - 635 Identifier: ISSN: 0804-4643