日本語
 
Help Privacy Policy ポリシー/免責事項
  詳細検索ブラウズ

アイテム詳細

登録内容を編集ファイル形式で保存
 
 
ダウンロード電子メール
 タグ情報を表示リリース履歴を表示詳細要約
  A Genome-wide Association Study of Early-Onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age

Ahsan, H., Halpern, J., Kibriya, M. G., Pierce, B. L., Tong, L., Gamazon, E., McGuire, V., Felberg, A., Shi, J., Jasmine, F., Roy, S., Brutus, R., Argos, M., Melkonian, S., Chang-Claude, J., Andrulis, I., Hopper, J. L., John, E. M., Malone, K., Ursin, G., Gammon, M. D., Thomas, D. C., Seminara, D., Casey, G., Knight, J. A., Southey, M. C., Giles, G. G., Santella, R. M., Lee, E., Conti, D., Duggan, D., Gallinger, S., Haile, R., Jenkins, M., Lindor, N. M., Newcomb, P., Michailidou, K., Apicella, C., Park, D. J., Peto, J., Fletcher, O., Silva, I. d. S., Lathrop, M., Hunter, D. J., Chanock, S. J., Meindl, A., Schmutzler, R. K., Müller-Myhsok, B., Lochmann, M., Beckmann, L., Hein, R., Makalic, E., Schmidt, D. F., Quang Bui, M., Stone, J., Flesch-Janys, D., Dahmen, N., Nevanlinna, H., Aittomaki, K., Blomqvist, C., Hall, P., Czene, K., Irwanto, A., Liu, J., Rahman, N., Turnbull, C., Dunning, A. M., Pharoah, P., Waisfisz, Q., Meijers-Heijboer, H., Uitterlinden, A. G., Rivadeneira, F., Nicolae, D., Easton, D. F., Cox, N. J., & Whittemore, A. S. (2014). A Genome-wide Association Study of Early-Onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 23(4), 658-669. doi:10.1158/1055-9965.EPI-13-0340.

Item is

 

表示: 全項目 非表示: 全項目

基本情報

表示: 非表示:
アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-0025-776D-0 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-0025-776E-E
資料種別: 学術論文

ファイル

表示: ファイル

関連URL

表示:

作成者

表示:
非表示:
 作成者:
Ahsan, Habibul1, 著者
Halpern, Jerry1, 著者
Kibriya, Muhammad G.1, 著者
Pierce, Brandon L.1, 著者
Tong, Lin1, 著者
Gamazon, Eric1, 著者
McGuire, Valerie1, 著者
Felberg, Anna1, 著者
Shi, Jianxin1, 著者
Jasmine, Farzana1, 著者
Roy, Shantanu1, 著者
Brutus, Rachelle1, 著者
Argos, Maria1, 著者
Melkonian, Stephanie1, 著者
Chang-Claude, Jenny1, 著者
Andrulis, Irene1, 著者
Hopper, John L.1, 著者
John, Esther M.1, 著者
Malone, Kathi1, 著者
Ursin, Giske1, 著者
Gammon, Marilie D.1, 著者Thomas, Duncan C.1, 著者Seminara, Daniela1, 著者Casey, Graham1, 著者Knight, Julia A.1, 著者Southey, Melissa C.1, 著者Giles, Graham G.1, 著者Santella, Regina M.1, 著者Lee, Eunjung1, 著者Conti, David1, 著者Duggan, David1, 著者Gallinger, Steve1, 著者Haile, Robert1, 著者Jenkins, Mark1, 著者Lindor, Noralane M.1, 著者Newcomb, Polly1, 著者Michailidou, Kyriaki1, 著者Apicella, Carmel1, 著者Park, Daniel J.1, 著者Peto, Julian1, 著者Fletcher, Olivia1, 著者Silva, Isabel dos Santos1, 著者Lathrop, Mark1, 著者Hunter, David J.1, 著者Chanock, Stephen J.1, 著者Meindl, Alfons1, 著者Schmutzler, Rita K.1, 著者Müller-Myhsok, Bertram2, 著者           Lochmann, Magdalena1, 著者Beckmann, Lars1, 著者Hein, Rebecca1, 著者Makalic, Enes1, 著者Schmidt, Daniel F.1, 著者Quang Bui, Minh1, 著者Stone, Jennifer1, 著者Flesch-Janys, Dieter1, 著者Dahmen, Norbert1, 著者Nevanlinna, Heli1, 著者Aittomaki, Kristiina1, 著者Blomqvist, Carl1, 著者Hall, Per1, 著者Czene, Kamila1, 著者Irwanto, Astrid1, 著者Liu, Jianjun1, 著者Rahman, Nazneen1, 著者Turnbull, Clare1, 著者Dunning, Alison M.1, 著者Pharoah, Paul1, 著者Waisfisz, Quinten1, 著者Meijers-Heijboer, Hanne1, 著者Uitterlinden, Andre G.1, 著者Rivadeneira, Fernando1, 著者Nicolae, Dan1, 著者Easton, Douglas F.1, 著者Cox, Nancy J.1, 著者Whittemore, Alice S.1, 著者 全て表示
所属:
1external, ou_persistent22              
2Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

内容説明

表示:
非表示:
キーワード: -
 要旨: Early-onset breast cancer (EOBC) causes substantial loss of life and productivity, creating a major burden among women worldwide. We analyzed 1,265,548 Hapmap3 single-nucleotide polymorphisms (SNP) among a discovery set of 3,523 EOBC incident cases and 2,702 population control women ages <= 51 years. The SNPs with smallest P values were examined in a replication set of 3,470EOBC cases and 5,475 control women. We also tested EOBC association with 19,684 genes by annotating each gene with putative functional SNPs, and then combining their P values to obtain a gene-based P value. We examined the gene with smallest P value for replication in 1,145 breast cancer cases and 1,142 control women. The combined discovery and replication sets identified 72 new SNPs associated with EOBC(P < 4 x 10(-8)) located in six genomic regions previously reported to contain SNPs associated largely with later-onset breast cancer (LOBC). SNP rs2229882 and 10 other SNPs on chromosome 5q11.2 remained associated (P < 6 x 10(-4)) after adjustment for the strongest published SNPs in the region. Thirty-two of the 82 currently known LOBC SNPs were associated with EOBC (P < 0.05). Low power is likely responsible for the remaining 50 unassociated known LOBC SNPs. The gene-based analysis identified an association between breast cancer and the phosphofructokinase-muscle (PFKM) gene on chromosome 12q13.11 that met the genome-wide gene-based threshold of 2.5 x 10(-6). In conclusion, EOBC and LOBC seem to have similar genetic etiologies; the 5q11.2 region may contain multiple distinct breast cancer loci; and the PFKM gene region is worthy of further investigation. These findings should enhance our understanding of the etiology of breast cancer. (C)2014 AACR.

資料詳細

表示:
非表示:
言語: eng - English
 日付: 2014-04
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: ISI: 000335145000011
DOI: 10.1158/1055-9965.EPI-13-0340
 学位: -

関連イベント

表示:

訴訟

表示:

Project information

表示:

出版物 1

表示:
非表示:
出版物名: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: American Association for Cancer Research
ページ: - 巻号: 23 (4) 通巻号: - 開始・終了ページ: 658 - 669 識別子（ISBN, ISSN, DOIなど）: ISSN: 1055-9965