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  Biological insights from 108 schizophrenia-associated genetic loci

Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K.-H., Holmans, P. A., et al. (2014). Biological insights from 108 schizophrenia-associated genetic loci. NATURE, 511(7510), 421-427. doi:10.1038/nature13595.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-8069-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-806A-A
Genre: Journal Article

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 Creators:
Ripke, Stephan1, Author
Neale, Benjamin M.1, Author
Corvin, Aiden1, Author
Walters, James T. R.1, Author
Farh, Kai-How1, Author
Holmans, Peter A.1, Author
Lee, Phil1, Author
Bulik-Sullivan, Brendan1, Author
Collier, David A.1, Author
Huang, Hailiang1, Author
Pers, Tune H.1, Author
Agartz, Ingrid1, Author
Agerbo, Esben1, Author
Albus, Margot1, Author
Alexander, Madeline1, Author
Amin, Farooq1, Author
Bacanu, Silviu A.1, Author
Begemann, Martin1, Author
Belliveau Jr., Richard A.1, Author
Bene, Judit1, Author
Bergen, Sarah E.1, AuthorBevilacqua, Elizabeth1, AuthorBigdeli, Tim B.1, AuthorBlack, Donald W.1, AuthorBruggeman, Richard1, AuthorBuccola, Nancy G.1, AuthorBuckner, Randy L.1, AuthorByerley, William1, AuthorCahn, Wiepke1, AuthorCai, Guiqing1, AuthorCampion, Dominique1, AuthorCantor, Rita M.1, AuthorCarr, Vaughan J.1, AuthorCarrera, Noa1, AuthorCatts, Stanley V.1, AuthorChambert, Kimberly D.1, AuthorChan, Raymond C. K.1, AuthorChen, Ronald Y. L.1, AuthorChen, Eric Y. H.1, AuthorCheng, Wei1, AuthorCheung, Eric F. C.1, AuthorChong, Siow Ann1, AuthorCloninger, C. Robert1, AuthorCohen, David1, AuthorCohen, Nadine1, AuthorCormican, Paul1, AuthorCraddock, Nick1, AuthorCrowley, James J.1, AuthorCurtis, David1, AuthorDavidson, Michael1, AuthorDavis, Kenneth L.1, AuthorDegenhardt, Franziska1, AuthorDel Favero, Jurgen1, AuthorDemontis, Ditte1, AuthorDikeos, Dimitris1, AuthorDinan, Timothy1, AuthorDjurovic, Srdjan1, AuthorDonohoe, Gary1, AuthorDrapeau, Elodie1, AuthorDuan, Jubao1, AuthorDudbridge, Frank1, AuthorDurmishi, Naser1, AuthorEichhammer, Peter1, AuthorEriksson, Johan1, AuthorEscott-Price, Valentina1, AuthorEssioux, Laurent1, AuthorFanous, Ayman H.1, AuthorFarrell, Martilias S.1, AuthorFrank, Josef1, AuthorFranke, Lude1, AuthorFreedman, Robert1, AuthorFreimer, Nelson B.1, AuthorFriedl, Marion1, AuthorFriedman, Joseph I.1, AuthorFromer, Menachem1, AuthorGenovese, Giulio1, AuthorGeorgieva, Lyudmila1, AuthorGiegling, Ina1, AuthorGiusti-Rodriguez, Paola1, AuthorGodard, Stephanie1, AuthorGoldstein, Jacqueline I.1, AuthorGolimbet, Vera1, AuthorGopal, Srihari1, AuthorGratten, Jacob1, Authorde Haan, Lieuwe1, AuthorHammer, Christian1, AuthorHamshere, Marian L.1, AuthorHansen, Mark1, AuthorHansen, Thomas1, AuthorHaroutunian, Vahram1, AuthorHartmann, Annette M.1, AuthorHenskens, Frans A.1, AuthorHerms, Stefan1, AuthorHirschhorn, Joel N.1, AuthorHoffmann, Per1, AuthorHofman, Andrea1, AuthorHollegaard, Mads V.1, AuthorHougaard, David M.1, AuthorIkeda, Masashi1, AuthorJoa, Inge1, AuthorJulia, Antonio1, AuthorKahn, Rene S.1, AuthorKalaydjieva, Luba1, AuthorKarachanak-Yankova, Sena1, AuthorKarjalainen, Juha1, AuthorKavanagh, David1, AuthorKeller, Matthew C.1, AuthorKennedy, James L.1, AuthorKhrunin, Andrey1, AuthorKim, Yunjung1, AuthorKlovins, Janis1, AuthorKnowles, James A.1, AuthorKonte, Bettina1, AuthorKucinskas, Vaidutis1, AuthorKucinskiene, Zita Ausrele1, AuthorKuzelova-Ptackova, Hana1, AuthorKahler, Anna K.1, AuthorLaurent, Claudine1, AuthorKeong, Jimmy Lee Chee1, AuthorLee, S. Hong1, AuthorLegge, Sophie E.1, AuthorLerer, Bernard1, AuthorLi, Miaoxin1, AuthorLi, Tao1, AuthorLiang, Kung-Yee1, AuthorLieberman, Jeffrey1, AuthorLimborska, Svetlana1, AuthorLoughland, Carmel M.1, AuthorLubinski, Jan1, AuthorLonnqvist, Jouko1, AuthorMacek Jr., Milan1, AuthorMagnusson, Patrik K. E.1, AuthorMaher, Brion S.1, AuthorMaier, Wolfgang1, AuthorMallet, Jacques1, AuthorMarsal, Sara1, AuthorMattheisen, Manuel1, AuthorMattingsdal, Morten1, AuthorMcCarley, Robert W.1, AuthorMcDonald, Colm1, AuthorMcIntosh, Andrew M.1, AuthorMeier, Sandra1, AuthorMeijer, Carin J.1, AuthorMelegh, Bela1, AuthorMelle, Ingrid1, AuthorMesholam-Gately, Raquelle I.1, AuthorMetspalu, Andres1, AuthorMichie, Patricia T.1, AuthorMilani, Lili1, AuthorMilanova, Vihra1, AuthorMokrab, Younes1, AuthorMorris, Derek W.1, AuthorMors, Ole1, AuthorMurphy, Kieran C.1, AuthorMurray, Robin M.1, AuthorMyin-Germeys, Inez1, AuthorMueller-Myhsok, Bertram2, Author           Nelis, Mari1, AuthorNenadic, Igor1, AuthorNertney, Deborah A.1, AuthorNestadt, Gerald1, AuthorNicodemus, Kristin K.1, AuthorNikitina-Zake, Liene1, AuthorNisenbaum, Laura1, AuthorNordin, Annelie1, AuthorO'Callaghan, Eadbhard1, AuthorO'Dushlaine, Colm1, AuthorO'Neill, F. Anthony1, AuthorOh, Sang-Yun1, AuthorOlincy, Ann1, AuthorOlsen, Line1, AuthorVan Os, Jim1, AuthorPantelis, Christos1, AuthorPapadimitriou, George N.1, AuthorPapiol, Sergi1, AuthorParkhomenko, Elena1, AuthorPato, Michele T.1, AuthorPaunio, Tiina1, AuthorPejovic-Milovancevic, Milica1, AuthorPerkins, Diana O.1, AuthorPietilainen, Olli1, AuthorPimm, Jonathan1, AuthorPocklington, Andrew J.1, AuthorPowell, John1, AuthorPrice, Alkes1, AuthorPulver, Ann E.1, AuthorPurcell, Shaun M.1, AuthorQuested, Digby1, AuthorRasmussen, Henrik B.1, AuthorReichenberg, Abraham1, AuthorReimers, Mark A.1, AuthorRichards, Alexander L.1, AuthorRoffman, Joshua L.1, AuthorRoussos, Panos1, AuthorRuderfer, Douglas M.1, AuthorSalomaa, Veikko1, AuthorSanders, Alan R.1, AuthorSchall, Ulrich1, AuthorSchubert, Christian R.1, AuthorSchulze, Thomas G.1, AuthorSchwab, Sibylle G.1, AuthorScolnick, Edward M.1, AuthorScott, Rodney J.1, AuthorSeidman, Larry J.1, AuthorShi, Jianxin1, AuthorSigurdsson, Engilbert1, AuthorSilagadze, Teimuraz1, AuthorSilverman, Jeremy M.1, AuthorSim, Kang1, AuthorSlominsky, Petr1, AuthorSmoller, Jordan W.1, AuthorSo, Hon-Cheong1, AuthorSpencer, Chris C. A.1, AuthorStahl, Eli A.1, AuthorStefansson, Hreinn1, AuthorSteinberg, Stacy1, AuthorStogmann, Elisabeth1, AuthorStraub, Richard E.1, AuthorStrengman, Eric1, AuthorStrohmaier, Jana1, AuthorStroup, T. Scott1, AuthorSubramaniam, Mythily1, AuthorSuvisaari, Jaana1, AuthorSvrakic, Dragan M.1, AuthorSzatkiewicz, Jin P.1, AuthorSoderman, Erik1, AuthorThirumalai, Srinivas1, AuthorToncheva, Draga1, AuthorTosato, Sarah1, AuthorVeijola, Juha1, AuthorWaddington, John1, AuthorWalsh, Dermot1, AuthorWang, Dai1, AuthorWang, Qiang1, AuthorWebb, Bradley T.1, AuthorWeiser, Mark1, AuthorWildenauer, Dieter B.1, AuthorWilliams, Nigel M.1, AuthorWilliams, Stephanie1, AuthorWitt, Stephanie H.1, AuthorWolen, Aaron R.1, AuthorWong, Emily H. M.1, AuthorWormley, Brandon K.1, AuthorXi, Hualin Simon1, AuthorZai, Clement C.1, AuthorZheng, Xuebin1, AuthorZimprich, Fritz1, AuthorWray, Naomi R.1, AuthorStefansson, Kari1, AuthorVisscher, Peter M.1, AuthorAdolfsson, Rolf1, AuthorAndreassen, Ole A.1, AuthorBlackwood, Douglas H. R.1, AuthorBramon, Elvira1, AuthorBuxbaum, Joseph D.1, AuthorBorglum, Anders D.1, AuthorCichon, Sven1, AuthorDarvasi, Ariel1, AuthorDomenici, Enrico1, AuthorEhrenreich, Hannelore1, AuthorEsko, Tonu1, AuthorGejman, Pablo V.1, AuthorGill, Michael1, AuthorGurling, Hugh1, AuthorHultman, Christina M.1, AuthorIwata, Nakao1, AuthorJablensky, Assen V.1, AuthorJonsson, Erik G.1, AuthorKendler, Kenneth S.1, AuthorKirov, George1, AuthorKnight, Jo1, AuthorLencz, Todd1, AuthorLevinson, Douglas F.1, AuthorLi, Qingqin S.1, AuthorLiu, Jianjun1, AuthorMalhotra, Anil K.1, AuthorMcCarroll, Steven A.1, AuthorMcQuillin, Andrew1, AuthorMoran, Jennifer L.1, AuthorMortensen, Preben B.1, AuthorMowry, Bryan J.1, AuthorNoethen, Markus M.1, AuthorOphoff, Roel A.1, AuthorOwen, Michael J.1, AuthorPalotie, Aarno1, AuthorPato, Carlos N.1, AuthorPetryshen, Tracey L.1, AuthorPosthuma, Danielle1, AuthorRietschel, Marcella1, AuthorRiley, Brien P.1, AuthorRujescu, Dan1, AuthorSham, Pak C.1, AuthorSklar, Pamela1, AuthorSt Clair, David1, AuthorWeinberger, Daniel R.1, AuthorWendland, Jens R.1, AuthorWerge, Thomas1, AuthorDaly, Mark J.1, AuthorSullivan, Patrick F.1, AuthorO'Donovan, Michael C.1, Author more..
Affiliations:
1external, ou_persistent22              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Abstract: Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.

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Language(s): eng - English
 Dates: 2014-07-24
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000339335700037
DOI: 10.1038/nature13595
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Title: NATURE
Source Genre: Journal
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Publ. Info: London : Macmillan Publishers Limited
Pages: - Volume / Issue: 511 (7510) Sequence Number: - Start / End Page: 421 - 427 Identifier: ISSN: 0028-0836