日本語
 
Help Privacy Policy ポリシー/免責事項
  詳細検索ブラウズ

アイテム詳細

登録内容を編集ファイル形式で保存
 
 
ダウンロード電子メール
 タグ情報を表示リリース履歴を表示詳細要約
  Biological insights from 108 schizophrenia-associated genetic loci

Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K.-H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau Jr., R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Degenhardt, F., Del Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Frank, J., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Genovese, G., Georgieva, L., Giegling, I., Giusti-Rodriguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Gratten, J., de Haan, L., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Herms, S., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Julia, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M. C., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kahler, A. K., Laurent, C., Keong, J. L. C., Lee, S. H., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K.-Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lonnqvist, J., Macek Jr., M., Magnusson, P. K. E., Maher, B. S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Mueller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C., O'Neill, F. A., Oh, S.-Y., Olincy, A., Olsen, L., Van Os, J., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietilainen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Ruderfer, D. M., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schulze, T. G., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H.-C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Strohmaier, J., Stroup, T. S., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Soderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Witt, S. H., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Wray, N. R., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Borglum, A. D., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jonsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Noethen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Rietschel, M., Riley, B. P., Rujescu, D., Sham, P. C., Sklar, P., St Clair, D., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., Sullivan, P. F., & O'Donovan, M. C. (2014). Biological insights from 108 schizophrenia-associated genetic loci. NATURE, 511(7510), 421-427. doi:10.1038/nature13595.

Item is

 

表示: 全項目 非表示: 全項目

基本情報

表示: 非表示:
アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-0024-8069-C 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-0024-806A-A
資料種別: 学術論文

ファイル

表示: ファイル

関連URL

表示:

作成者

表示:
非表示:
 作成者:
Ripke, Stephan1, 著者
Neale, Benjamin M.1, 著者
Corvin, Aiden1, 著者
Walters, James T. R.1, 著者
Farh, Kai-How1, 著者
Holmans, Peter A.1, 著者
Lee, Phil1, 著者
Bulik-Sullivan, Brendan1, 著者
Collier, David A.1, 著者
Huang, Hailiang1, 著者
Pers, Tune H.1, 著者
Agartz, Ingrid1, 著者
Agerbo, Esben1, 著者
Albus, Margot1, 著者
Alexander, Madeline1, 著者
Amin, Farooq1, 著者
Bacanu, Silviu A.1, 著者
Begemann, Martin1, 著者
Belliveau Jr., Richard A.1, 著者
Bene, Judit1, 著者
Bergen, Sarah E.1, 著者Bevilacqua, Elizabeth1, 著者Bigdeli, Tim B.1, 著者Black, Donald W.1, 著者Bruggeman, Richard1, 著者Buccola, Nancy G.1, 著者Buckner, Randy L.1, 著者Byerley, William1, 著者Cahn, Wiepke1, 著者Cai, Guiqing1, 著者Campion, Dominique1, 著者Cantor, Rita M.1, 著者Carr, Vaughan J.1, 著者Carrera, Noa1, 著者Catts, Stanley V.1, 著者Chambert, Kimberly D.1, 著者Chan, Raymond C. K.1, 著者Chen, Ronald Y. L.1, 著者Chen, Eric Y. H.1, 著者Cheng, Wei1, 著者Cheung, Eric F. C.1, 著者Chong, Siow Ann1, 著者Cloninger, C. Robert1, 著者Cohen, David1, 著者Cohen, Nadine1, 著者Cormican, Paul1, 著者Craddock, Nick1, 著者Crowley, James J.1, 著者Curtis, David1, 著者Davidson, Michael1, 著者Davis, Kenneth L.1, 著者Degenhardt, Franziska1, 著者Del Favero, Jurgen1, 著者Demontis, Ditte1, 著者Dikeos, Dimitris1, 著者Dinan, Timothy1, 著者Djurovic, Srdjan1, 著者Donohoe, Gary1, 著者Drapeau, Elodie1, 著者Duan, Jubao1, 著者Dudbridge, Frank1, 著者Durmishi, Naser1, 著者Eichhammer, Peter1, 著者Eriksson, Johan1, 著者Escott-Price, Valentina1, 著者Essioux, Laurent1, 著者Fanous, Ayman H.1, 著者Farrell, Martilias S.1, 著者Frank, Josef1, 著者Franke, Lude1, 著者Freedman, Robert1, 著者Freimer, Nelson B.1, 著者Friedl, Marion1, 著者Friedman, Joseph I.1, 著者Fromer, Menachem1, 著者Genovese, Giulio1, 著者Georgieva, Lyudmila1, 著者Giegling, Ina1, 著者Giusti-Rodriguez, Paola1, 著者Godard, Stephanie1, 著者Goldstein, Jacqueline I.1, 著者Golimbet, Vera1, 著者Gopal, Srihari1, 著者Gratten, Jacob1, 著者de Haan, Lieuwe1, 著者Hammer, Christian1, 著者Hamshere, Marian L.1, 著者Hansen, Mark1, 著者Hansen, Thomas1, 著者Haroutunian, Vahram1, 著者Hartmann, Annette M.1, 著者Henskens, Frans A.1, 著者Herms, Stefan1, 著者Hirschhorn, Joel N.1, 著者Hoffmann, Per1, 著者Hofman, Andrea1, 著者Hollegaard, Mads V.1, 著者Hougaard, David M.1, 著者Ikeda, Masashi1, 著者Joa, Inge1, 著者Julia, Antonio1, 著者Kahn, Rene S.1, 著者Kalaydjieva, Luba1, 著者Karachanak-Yankova, Sena1, 著者Karjalainen, Juha1, 著者Kavanagh, David1, 著者Keller, Matthew C.1, 著者Kennedy, James L.1, 著者Khrunin, Andrey1, 著者Kim, Yunjung1, 著者Klovins, Janis1, 著者Knowles, James A.1, 著者Konte, Bettina1, 著者Kucinskas, Vaidutis1, 著者Kucinskiene, Zita Ausrele1, 著者Kuzelova-Ptackova, Hana1, 著者Kahler, Anna K.1, 著者Laurent, Claudine1, 著者Keong, Jimmy Lee Chee1, 著者Lee, S. Hong1, 著者Legge, Sophie E.1, 著者Lerer, Bernard1, 著者Li, Miaoxin1, 著者Li, Tao1, 著者Liang, Kung-Yee1, 著者Lieberman, Jeffrey1, 著者Limborska, Svetlana1, 著者Loughland, Carmel M.1, 著者Lubinski, Jan1, 著者Lonnqvist, Jouko1, 著者Macek Jr., Milan1, 著者Magnusson, Patrik K. E.1, 著者Maher, Brion S.1, 著者Maier, Wolfgang1, 著者Mallet, Jacques1, 著者Marsal, Sara1, 著者Mattheisen, Manuel1, 著者Mattingsdal, Morten1, 著者McCarley, Robert W.1, 著者McDonald, Colm1, 著者McIntosh, Andrew M.1, 著者Meier, Sandra1, 著者Meijer, Carin J.1, 著者Melegh, Bela1, 著者Melle, Ingrid1, 著者Mesholam-Gately, Raquelle I.1, 著者Metspalu, Andres1, 著者Michie, Patricia T.1, 著者Milani, Lili1, 著者Milanova, Vihra1, 著者Mokrab, Younes1, 著者Morris, Derek W.1, 著者Mors, Ole1, 著者Murphy, Kieran C.1, 著者Murray, Robin M.1, 著者Myin-Germeys, Inez1, 著者Mueller-Myhsok, Bertram2, 著者           Nelis, Mari1, 著者Nenadic, Igor1, 著者Nertney, Deborah A.1, 著者Nestadt, Gerald1, 著者Nicodemus, Kristin K.1, 著者Nikitina-Zake, Liene1, 著者Nisenbaum, Laura1, 著者Nordin, Annelie1, 著者O'Callaghan, Eadbhard1, 著者O'Dushlaine, Colm1, 著者O'Neill, F. Anthony1, 著者Oh, Sang-Yun1, 著者Olincy, Ann1, 著者Olsen, Line1, 著者Van Os, Jim1, 著者Pantelis, Christos1, 著者Papadimitriou, George N.1, 著者Papiol, Sergi1, 著者Parkhomenko, Elena1, 著者Pato, Michele T.1, 著者Paunio, Tiina1, 著者Pejovic-Milovancevic, Milica1, 著者Perkins, Diana O.1, 著者Pietilainen, Olli1, 著者Pimm, Jonathan1, 著者Pocklington, Andrew J.1, 著者Powell, John1, 著者Price, Alkes1, 著者Pulver, Ann E.1, 著者Purcell, Shaun M.1, 著者Quested, Digby1, 著者Rasmussen, Henrik B.1, 著者Reichenberg, Abraham1, 著者Reimers, Mark A.1, 著者Richards, Alexander L.1, 著者Roffman, Joshua L.1, 著者Roussos, Panos1, 著者Ruderfer, Douglas M.1, 著者Salomaa, Veikko1, 著者Sanders, Alan R.1, 著者Schall, Ulrich1, 著者Schubert, Christian R.1, 著者Schulze, Thomas G.1, 著者Schwab, Sibylle G.1, 著者Scolnick, Edward M.1, 著者Scott, Rodney J.1, 著者Seidman, Larry J.1, 著者Shi, Jianxin1, 著者Sigurdsson, Engilbert1, 著者Silagadze, Teimuraz1, 著者Silverman, Jeremy M.1, 著者Sim, Kang1, 著者Slominsky, Petr1, 著者Smoller, Jordan W.1, 著者So, Hon-Cheong1, 著者Spencer, Chris C. A.1, 著者Stahl, Eli A.1, 著者Stefansson, Hreinn1, 著者Steinberg, Stacy1, 著者Stogmann, Elisabeth1, 著者Straub, Richard E.1, 著者Strengman, Eric1, 著者Strohmaier, Jana1, 著者Stroup, T. Scott1, 著者Subramaniam, Mythily1, 著者Suvisaari, Jaana1, 著者Svrakic, Dragan M.1, 著者Szatkiewicz, Jin P.1, 著者Soderman, Erik1, 著者Thirumalai, Srinivas1, 著者Toncheva, Draga1, 著者Tosato, Sarah1, 著者Veijola, Juha1, 著者Waddington, John1, 著者Walsh, Dermot1, 著者Wang, Dai1, 著者Wang, Qiang1, 著者Webb, Bradley T.1, 著者Weiser, Mark1, 著者Wildenauer, Dieter B.1, 著者Williams, Nigel M.1, 著者Williams, Stephanie1, 著者Witt, Stephanie H.1, 著者Wolen, Aaron R.1, 著者Wong, Emily H. M.1, 著者Wormley, Brandon K.1, 著者Xi, Hualin Simon1, 著者Zai, Clement C.1, 著者Zheng, Xuebin1, 著者Zimprich, Fritz1, 著者Wray, Naomi R.1, 著者Stefansson, Kari1, 著者Visscher, Peter M.1, 著者Adolfsson, Rolf1, 著者Andreassen, Ole A.1, 著者Blackwood, Douglas H. R.1, 著者Bramon, Elvira1, 著者Buxbaum, Joseph D.1, 著者Borglum, Anders D.1, 著者Cichon, Sven1, 著者Darvasi, Ariel1, 著者Domenici, Enrico1, 著者Ehrenreich, Hannelore1, 著者Esko, Tonu1, 著者Gejman, Pablo V.1, 著者Gill, Michael1, 著者Gurling, Hugh1, 著者Hultman, Christina M.1, 著者Iwata, Nakao1, 著者Jablensky, Assen V.1, 著者Jonsson, Erik G.1, 著者Kendler, Kenneth S.1, 著者Kirov, George1, 著者Knight, Jo1, 著者Lencz, Todd1, 著者Levinson, Douglas F.1, 著者Li, Qingqin S.1, 著者Liu, Jianjun1, 著者Malhotra, Anil K.1, 著者McCarroll, Steven A.1, 著者McQuillin, Andrew1, 著者Moran, Jennifer L.1, 著者Mortensen, Preben B.1, 著者Mowry, Bryan J.1, 著者Noethen, Markus M.1, 著者Ophoff, Roel A.1, 著者Owen, Michael J.1, 著者Palotie, Aarno1, 著者Pato, Carlos N.1, 著者Petryshen, Tracey L.1, 著者Posthuma, Danielle1, 著者Rietschel, Marcella1, 著者Riley, Brien P.1, 著者Rujescu, Dan1, 著者Sham, Pak C.1, 著者Sklar, Pamela1, 著者St Clair, David1, 著者Weinberger, Daniel R.1, 著者Wendland, Jens R.1, 著者Werge, Thomas1, 著者Daly, Mark J.1, 著者Sullivan, Patrick F.1, 著者O'Donovan, Michael C.1, 著者 全て表示
所属:
1external, ou_persistent22              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

内容説明

表示:
非表示:
キーワード: -
 要旨: Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.

資料詳細

表示:
非表示:
言語: eng - English
 日付: 2014-07-24
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: ISI: 000339335700037
DOI: 10.1038/nature13595
 学位: -

関連イベント

表示:

訴訟

表示:

Project information

表示:

出版物 1

表示:
非表示:
出版物名: NATURE
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: London : Macmillan Publishers Limited
ページ: - 巻号: 511 (7510) 通巻号: - 開始・終了ページ: 421 - 427 識別子（ISBN, ISSN, DOIなど）: ISSN: 0028-0836