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  Local CRH Signaling Promotes Synaptogenesis and Circuit Integration of Adult-Born Neurons

Garcia, I., Quast, K. B., Huang, L., Herman, A. M., Selever, J., Deussing, J. M., et al. (2014). Local CRH Signaling Promotes Synaptogenesis and Circuit Integration of Adult-Born Neurons. DEVELOPMENTAL CELL, 30(6), 645-659. doi:10.1016/j.devcel.2014.07.001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-5ED3-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-5ED4-7
Genre: Journal Article

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 Creators:
Garcia, Isabella1, Author
Quast, Kathleen B.1, Author
Huang, Longwen1, Author
Herman, Alexander M.1, Author
Selever, Jennifer1, Author
Deussing, Jan Michael2, Author              
Justice, Nicholas J.1, Author
Arenkiel, Benjamin R.1, Author
Affiliations:
1external, ou_persistent22              
2Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294              

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 Abstract: Neural activity either enhances or impairs de novo synaptogenesis and circuit integration of neurons, but how this activity is mechanistically relayed in the adult brain is largely unknown. Neuropeptide-expressing interneurons are widespread throughout the brain and are key candidates for conveying neural activity downstream via neuromodulatory pathways that are distinct from classical neurotransmission. With the goal of identifying signaling mechanisms that underlie neuronal circuit integration in the adult brain, we have virally traced local corticotropin-releasing hormone (CRH)-expressing inhibitory interneurons with extensive presynaptic inputs onto new neurons that are continuously integrated into the adult rodent olfactory bulb. Local CRH signaling onto adult-born neurons promotes and/or stabilizes chemical synapses in the olfactory bulb, revealing a neuromodulatory mechanism for continued circuit plasticity, synapse formation, and integration of new neurons in the adult brain.

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Language(s): eng - English
 Dates: 2014-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
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Title: DEVELOPMENTAL CELL
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 30 (6) Sequence Number: - Start / End Page: 645 - 659 Identifier: ISSN: 1534-5807