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  Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure.

Schmidtgall, B., Spork, A. P., Wachowius, F., Höbartner, C., & Ducho, C. (2014). Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure. Chemical Communications, 50(89), 13742-13745. doi:10.1039/C4CC06371F.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-445C-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-C005-B
Genre: Journal Article

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Schmidtgall, B., Author
Spork, A. P., Author
Wachowius, F.1, Author              
Höbartner, C.1, Author              
Ducho, C., Author
Affiliations:
1Research Group of Nucleic Acid Chemistry, MPI for biophysical chemistry, Max Planck Society, ou_578605              

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 Abstract: The nucleosyl amino acid (NAA)-modification of oligonucleotides is introduced, which enables the preparation of oligonucleotides with zwitterionic backbone structures. It is demonstrated that partially zwitterionic NAA-modified DNA oligonucleotides are capable of duplex formation with native polyanionic counterstrands and show retained sensitivity towards base-pairing mismatches.

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Language(s): eng - English
 Dates: 2014-09-082014-11-18
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1039/C4CC06371F
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Title: Chemical Communications
Source Genre: Journal
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Pages: - Volume / Issue: 50 (89) Sequence Number: - Start / End Page: 13742 - 13745 Identifier: -