English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Towards quantification of pulsed spinlock and CEST at clinical MR scanners: An analytical interleaved saturation-relaxation (ISAR) approach.

Roeloffs, V. B., Meyer, C., Bachert, P., & Zaiss, M. (2015). Towards quantification of pulsed spinlock and CEST at clinical MR scanners: An analytical interleaved saturation-relaxation (ISAR) approach. NMR in Biomedicine, 28(1), 40-53. doi:10.1002/nbm.3192.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-465C-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-22F4-9
Genre: Journal Article

Files

show Files
hide Files
:
2076249.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
2076249.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute), Göttingen; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Roeloffs, V. B.1, Author              
Meyer, C., Author
Bachert, P., Author
Zaiss, M., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society, ou_578634              

Content

show
hide
Free keywords: chemical exchange; CEST; spinlock; pulsed saturation; magnetization transfer, MT; amide proton transfer, APT
 Abstract: Off-resonant spinlock (SL) enables an NMR imaging technique that can detect dilute metabolites similar to chemical exchange saturation transfer. However, in clinical MR scanners, RF pulse widths are restricted due to recommended specific absorption rate limits. Therefore, trains of short RF pulses that provide effective saturation during the required irradiation period are commonly employed. Quantitative evaluation of spectra obtained by pulsed saturation schemes is harder to achieve, since the theory of continuous wave saturation cannot be applied directly. In this paper we demonstrate the general feasibility of quantifying proton exchange rates from data obtained in pulsed SL experiments on a clinical 3 T MR scanner. We also propose a theoretical treatment of pulsed SL in the presence of chemical exchange using an interleaved saturation-relaxation approach. We show that modeling magnetization transfer during the pauses between the RF pulses is crucial, especially in the case of exchange rates that are small with respect to the delay times. The dynamics is still governed by a monoexponential decay towards steady state, for which we give the effective rate constant. The derived analytical model agrees well with the full numerical simulation of the Bloch-McConnell equations for a broad range of values of the system parameters.

Details

show
hide
Language(s): eng - English
 Dates: 2014-10-182015-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/nbm.3192
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: NMR in Biomedicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 28 (1) Sequence Number: - Start / End Page: 40 - 53 Identifier: -