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  Side-Chain Orientation and Hydrogen-Bonding Imprint Supra-τc Motion on the Protein Backbone of Ubiquitin

Lakomek, N. A., Farès, C., Becker, S., Carlomagno, T., Meiler, J., & Griesinger, C. (2005). Side-Chain Orientation and Hydrogen-Bonding Imprint Supra-τc Motion on the Protein Backbone of Ubiquitin. Angewandte Chemie International Edition, 44(47), 7776-7778. doi:10.1002/anie.200502573.

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 Creators:
Lakomek, Nils A.1, Author
Farès, Christophe2, Author           
Becker, Stefan1, Author
Carlomagno, Teresa1, Author
Meiler, Jens3, Author
Griesinger, Christian1, Author
Affiliations:
1Max Planck Institut für Biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen, Germany, Fax: (+49) 551-201-2202, ou_persistent22              
2Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_578567              
3Vanderbilt University, Department of Chemistry, Center of Structural Biology, 465 21st Ave South, Nashville, TN 37232‐8725, USA, Fax: (+1) 615‐936‐2211, ou_persistent22              

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Free keywords: molecular dynamics; natural products; NMr spectrocopy; protein structures
 Abstract: Order parameters derived from residual dipolar couplings between NH groups reveal motion of protein backbones on a time scale slower than the correlation time τC. Less‐mobile amides (blue and green) in ubiquitin, for example, are H‐bonded and belong to residues with side chains pointing towards the hydrophobic core while more mobile ones (yellow, orange, and red) have solvent‐exposed side chains and fewer H bonds.

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Language(s): eng - English
 Dates: 2005-07-222005-11-082005-12-02
 Publication Status: Published in print
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.200502573
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 44 (47) Sequence Number: - Start / End Page: 7776 - 7778 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851