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  Side-Chain Orientation and Hydrogen-Bonding Imprint Supra-τc Motion on the Protein Backbone of Ubiquitin

Lakomek, N., Farès, C., Becker, S., Carlomango, T., Meiler, J., & Griesinger, C. (2005). Side-Chain Orientation and Hydrogen-Bonding Imprint Supra-τc Motion on the Protein Backbone of Ubiquitin. Angewandte Chemie International Edition: a journal of the Gesellschaft Deutscher Chemiker, 44(47), 7776-7778. doi:10.1002/anie.200502573.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-4B32-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-4B33-8
Genre: Journal Article

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 Creators:
Lakomek, N.A.1, Author
Farès, C.1, 2, Author              
Becker, S.1, Author
Carlomango, T.1, Author
Meiler, J.3, Author
Griesinger, C.1, Author
Affiliations:
1Max Planck Institut für Biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen, Germany, Fax: (+49) 551-201-2202, ou_persistent22              
2Service Department Farès (NMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445623              
3Vanderbilt University, Department of Chemistry, Center of Structural Biology, 465 21st Ave South, Nashville, TN 37232-8725, USA, Fax: (+1) 615-936-2211, ou_persistent22              

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Free keywords: lecular dynamics; natural products; NMR spectroscopy; protein structures
 Abstract: Thumbnail image of graphical abstract Order parameters derived from residual dipolar couplings between NH groups reveal motion of protein backbones on a time scale slower than the correlation time τC. Less-mobile amides (blue and green) in ubiquitin, for example, are H-bonded and belong to residues with side chains pointing towards the hydrophobic core while more mobile ones (yellow, orange, and red) have solvent-exposed side chains and fewer H bonds.

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Language(s): eng - English
 Dates: 2005-11-082005-12-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/anie.200502573
 Degree: -

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Title: Angewandte Chemie International Edition: a journal of the Gesellschaft Deutscher Chemiker
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 44 (47) Sequence Number: - Start / End Page: 7776 - 7778 Identifier: ISSN: 0570-0833
CoNE: /journals/resource/110984073528720