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  Solving the orientation specific constraints in transcranial magnetic stimulation by rotating fields

Rotem, A., Neef, A., Neef, N., Agudelo-Toro, A., Rakhmilevitch, D., Paulus, W., et al. (2014). Solving the orientation specific constraints in transcranial magnetic stimulation by rotating fields. PLoS One, 9(2): e86794. doi:10.1371/journal.pone.0086794.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-4E23-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8380-7
Genre: Journal Article

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© 2014 Rotem et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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 Creators:
Rotem, Assaf1, Author
Neef, Andreas2, Author
Neef, Nicole3, 4, Author              
Agudelo-Toro, Andres5, Author
Rakhmilevitch, David6, Author
Paulus, Walter4, Author
Moses, Elisha7, Author
Affiliations:
1Department of Physics and SEAS, Harvard University, Cambridge, Massachusetts, USA, ou_persistent22              
2Bernstein Center for Computational Neuroscience, Goettingen, Germany, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
4Department of Clinical Neurophysiology, University Medicine Goettingen, Germany, ou_persistent22              
5Max Planck Institute for Dynamics and Self-Organization, Goettingen, Germany, ou_persistent22              
6Chemical Physics Department, Weizmann Institute of Science, Rehovot, Israel, ou_persistent22              
7Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel, ou_persistent22              

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 Abstract: Transcranial Magnetic Stimulation (TMS) is a promising technology for both neurology and psychiatry. Positive treatment outcome has been reported, for instance in double blind, multi-center studies on depression. Nonetheless, the application of TMS towards studying and treating brain disorders is still limited by inter-subject variability and lack of model systems accessible to TMS. The latter are required to obtain a deeper understanding of the biophysical foundations of TMS so that the stimulus protocol can be optimized for maximal brain response, while inter-subject variability hinders precise and reliable delivery of stimuli across subjects. Recent studies showed that both of these limitations are in part due to the angular sensitivity of TMS. Thus, a technique that would eradicate the need for precise angular orientation of the coil would improve both the inter-subject reliability of TMS and its effectiveness in model systems. We show here how rotation of the stimulating field relieves the angular sensitivity of TMS and provides improvements in both issues. Field rotation is attained by superposing the fields of two coils positioned orthogonal to each other and operated with a relative phase shift in time. Rotating field TMS (rfTMS) efficiently stimulates both cultured hippocampal networks and rat motor cortex, two neuronal systems that are notoriously difficult to excite magnetically. This opens the possibility of pharmacological and invasive TMS experiments in these model systems. Application of rfTMS to human subjects overcomes the orientation dependence of standard TMS. Thus, rfTMS yields optimal targeting of brain regions where correct orientation cannot be determined (e.g., via motor feedback) and will enable stimulation in brain regions where a preferred axonal orientation does not exist.

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Language(s): eng - English
 Dates: 2013-08-312013-12-132014-02-05
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0086794
PMID: 24505266
PMC: PMC3914799
Other: eCollection 2014
 Degree: -

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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: 10 Volume / Issue: 9 (2) Sequence Number: e86794 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850