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  Grey matter changes in motor conversion disorder

Aybek, S., Nicholson, T. R. J., Draganski, B., Daly, E., Murphy, D. G., David, A. S., et al. (2014). Grey matter changes in motor conversion disorder. Journal of Neurology, Neurosurgery & Psychiatry, 85(2), 236-238. doi:10.1136/jnnp-2012-304158.

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 Creators:
Aybek, Selma1, 2, Author
Nicholson, Timothy R. J.1, Author
Draganski, Bogdan2, 3, 4, Author              
Daly, Eileen5, Author
Murphy, Declan G.5, Author
David, Anthony S.1, Author
Kanaan, Richard A.1, Author
Affiliations:
1Section of Cognitive Neuropsychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom, ou_persistent22              
2Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom, ou_persistent22              

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 Abstract: Objective: To detect anatomical differences in areas related to motor processing between patients with motor conversion disorder (CD) and controls. Methods: T1-weighted 3T brain MRI data of 15 patients suffering from motor CD (nine with hemiparesis and six with paraparesis) and 25 age- and gender-matched healthy volunteers were compared using voxel-based morphometry (VBM) and voxel-based cortical thickness (VBCT) analysis. Results: We report significant cortical thickness (VBCT) increases in the bilateral premotor cortex of hemiparetic patients relative to controls and a trend towards increased grey matter volume (VBM) in the same region. Regression analyses showed a non-significant positive correlation between cortical thickness changes and symptom severity as well as illness duration in CD patients. Conclusions: Cortical thickness increases in premotor cortical areas of patients with hemiparetic CD provide evidence for altered brain structure in a condition with presumed normal brain anatomy. These may either represent premorbid vulnerability or a plasticity phenomenon related to the disease with the trends towards correlations with clinical variables supporting the latter.

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Language(s): eng - English
 Dates: 2012-11-142012-12-122014-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1136/jnnp-2012-304158
PMID: 23236016
Other: Epub 2012
 Degree: -

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Title: Journal of Neurology, Neurosurgery & Psychiatry
Source Genre: Journal
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Publ. Info: London : British Medical Association
Pages: - Volume / Issue: 85 (2) Sequence Number: - Start / End Page: 236 - 238 Identifier: ISSN: 0022-3050
CoNE: https://pure.mpg.de/cone/journals/resource/111085522793000