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  Ventral striatal prediction error signaling is associated with dopamine synthesis capacity and fluid intelligence

Schlagenhauf, F., Rapp, M. A., Huys, Q. J. M., Beck, A., Wüstenberg, T., Deserno, L., et al. (2013). Ventral striatal prediction error signaling is associated with dopamine synthesis capacity and fluid intelligence. Human Brain Mapping, 34(6), 1490-1499. doi:10.1002/hbm.22000.

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 Creators:
Schlagenhauf, Florian1, Author              
Rapp, Michael A.1, Author
Huys, Quentin J. M.2, 3, Author
Beck, Anne1, Author
Wüstenberg, Torsten1, Author
Deserno, Lorenz1, Author              
Buchholz, Hans-Georg4, Author
Kalbitzer, Jan1, Author
Buchert, Ralph5, Author
Bauer, Michael6, Author
Kienast, Thorsten1, Author
Cumming, Paul7, Author
Plotkin, Michail5, Author
Kumakura, Yoshitaka8, Author
Grace, Anthony A.9, 10, 11, Author
Dolan, Raymond J.3, Author
Heinz, Andreas1, 12, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
3Gatsby Computational Neuroscience Unit, University College London, United Kingdom, ou_persistent22              
4Department of Nuclear Medicine, Johannes Gutenberg University, Mainz, Germany, ou_persistent22              
5Department of Nuclear Medicine, Charité University Medicine Berlin, Germany, ou_persistent22              
6Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden, Germany, ou_persistent22              
7Department of Nuclear Medicine, Ludwig Maximilians University Munich, Germany, ou_persistent22              
8Ministry of Health, Labour and Welfare, Kanto Rosai Hospital, Kawasaki, Japan, ou_persistent22              
9Department of Neuroscience, University of Pittsburgh, PA, USA, ou_persistent22              
10Department of Psychiatry, University of Pittsburgh, PA, USA, ou_persistent22              
11Department of Psychology, University of Pittsburgh, PA, USA, ou_persistent22              
12NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Prediction error; Dopamine synthesis; Fluid intelligence; Ventral striatum; fMRI; FDOPA PET
 Abstract: Fluid intelligence represents the capacity for flexible problem solving and rapid behavioral adaptation. Rewards drive flexible behavioral adaptation, in part via a teaching signal expressed as reward prediction errors in the ventral striatum, which has been associated with phasic dopamine release in animal studies. We examined a sample of 28 healthy male adults using multimodal imaging and biological parametric mapping with (1) functional magnetic resonance imaging during a reversal learning task and (2) in a subsample of 17 subjects also with positron emission tomography using 6-[18F]fluoro-L-DOPA to assess dopamine synthesis capacity. Fluid intelligence was measured using a battery of nine standard neuropsychological tests. Ventral striatal BOLD correlates of reward prediction errors were positively correlated with fluid intelligence and, in the right ventral striatum, also inversely correlated with dopamine synthesis capacity (FDOPA Kmath image). When exploring aspects of fluid intelligence, we observed that prediction error signaling correlates with complex attention and reasoning. These findings indicate that individual differences in the capacity for flexible problem solving relate to ventral striatal activation during reward-related learning, which in turn proved to be inversely associated with ventral striatal dopamine synthesis capacity.

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Language(s): eng - English
 Dates: 2011-10-112011-08-092011-11-082012-02-172013-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.22000
PMID: 22344813
PMC: PMC3731774
Other: Epub 2012
 Degree: -

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 34 (6) Sequence Number: - Start / End Page: 1490 - 1499 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686