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  Model-based and model-free decisions in alcohol dependence

Sebold, M., Deserno, L., Nebe, S., Schad, D. J., Garbusow, M., Hägele, C., et al. (2014). Model-based and model-free decisions in alcohol dependence. Neuropsychobiology, 70(2), 122-131. doi:10.1159/000362840.

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 Creators:
Sebold, M.1, Author
Deserno, Lorenz1, 2, Author              
Nebe, S.3, Author
Schad, D. J.1, Author
Garbusow, M.1, Author
Hägele, C.1, Author
Keller, J.1, Author
Jünger, E.4, Author
Kathmann, N.5, Author
Smolka, M. N.3, Author
Rapp, M. A.6, Author
Schlagenhauf, Florian1, 2, Author              
Heinz, A.1, Author
Huys, Q. J. M.7, 8, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Max Planck Fellow Group Cognitive and Affective Control of Behavioural Adaptation, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1753350              
3Section of Systems Neuroscience, Department of Psychiatry and Psychotherapy, TU Dresden, Germany, ou_persistent22              
4Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden, Germany, ou_persistent22              
5Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
6Cognitive Sciences Area of Excellence, Department of Social and Preventive Medicine, University of Potsdam, Germany, ou_persistent22              
7Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich, Switzerland, ou_persistent22              
8Department of Psychiatry and Psychotherapy, University Hospital Zurich, Germany, ou_persistent22              

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Free keywords: Alcohol dependence; Decision-making; Reinforcement learning; Dopamine; Computational psychiatry

 Abstract: Background: Human and animal work suggests a shift from goal-directed to habitual decision-making in addiction. However, the evidence for this in human alcohol dependence is as yet inconclusive. Methods: Twenty-six healthy controls and 26 recently detoxified alcohol-dependent patients underwent behavioral testing with a 2-step task designed to disentangle goal-directed and habitual response patterns. Results: Alcohol-dependent patients showed less evidence of goal-directed choices than healthy controls, particularly after losses. There was no difference in the strength of the habitual component. The group differences did not survive controlling for performance on the Digit Symbol Substitution Task. Conclusion: Chronic alcohol use appears to selectively impair goal-directed function, rather than promoting habitual responding. It appears to do so particularly after nonrewards, and this may be mediated by the effects of alcohol on more general cognitive functions subserved by the prefrontal cortex.

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Language(s): eng - English
 Dates: 2013-10-072014-04-132014-10-302014-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1159/000362840
PMID: 25359492
Other: Epub 2014
 Degree: -

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Title: Neuropsychobiology
Source Genre: Journal
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Publ. Info: Basel : Karger
Pages: - Volume / Issue: 70 (2) Sequence Number: - Start / End Page: 122 - 131 Identifier: ISSN: 0302-282X
CoNE: https://pure.mpg.de/cone/journals/resource/954925510411