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  Assessment of disintegrant efficacy with fractal dimensions from real-time MRI.

Quodbach, J., Moussavi, A., Tammer, R., Frahm, J., & Kleinebudde, P. (2014). Assessment of disintegrant efficacy with fractal dimensions from real-time MRI. International Journal of Pharmaceutics, 475(1-2), 605-612. doi:10.1016/j.ijpharm.2014.09.021.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-5C8C-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-BC04-C
Genre: Journal Article

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 Creators:
Quodbach, J., Author
Moussavi, A.1, Author              
Tammer, R.1, Author              
Frahm, J.1, Author              
Kleinebudde, P., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: Formulation; Polymers; Visualization; Superdisintegrants; Tablet disintegration
 Abstract: An efficient disintegrant is capable of breaking up a tablet in the smallest possible particles in the shortest time. Until now, comparative data on the efficacy of different disintegrants is based on dissolution studies or the disintegration time. Extending these approaches, this study introduces a method, which defines the evolution of fractal dimensions of tablets as surrogate parameter for the available surface area. Fractal dimensions are a measure for the tortuosity of a line, in this case the upper surface of a disintegrating tablet. High-resolution real-time MRI was used to record videos of disintegrating tablets. The acquired video images were processed to depict the upper surface of the tablets and a box-counting algorithm was used to estimate the fractal dimensions. The influence of six different disintegrants, of different relative tablet density, and increasing disintegrant concentration was investigated to evaluate the performance of the novel method. Changing relative densities hardly affect the progression of fractal dimensions, whereas an increase in disintegrant concentration causes increasing fractal dimensions during disintegration, which are also reached quicker. Different disintegrants display only minor differences in the maximal fractal dimension, yet the kinetic in which the maximum is reached allows a differentiation and classification of disintegrants.

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Language(s): eng - English
 Dates: 2014-09-162014-11-20
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.ijpharm.2014.09.021
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Title: International Journal of Pharmaceutics
Source Genre: Journal
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Pages: - Volume / Issue: 475 (1-2) Sequence Number: - Start / End Page: 605 - 612 Identifier: -