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  Crystal Structures of [Fe]-Hydrogenase in Complex with Inhibitory Isocyanides: Implications for the H2-Activation Site

Tamura, H., Salomone-Stagni, M., Fujishiro, T., Warkentin, E., Meyer-Klaucke, W., Ermler, U., et al. (2013). Crystal Structures of [Fe]-Hydrogenase in Complex with Inhibitory Isocyanides: Implications for the H2-Activation Site. Angewandte Chemie, International Edition in English, 52(37), 9656-9659. doi:10.1002/anie.201305089.

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 Creators:
Tamura, Haruka1, Author
Salomone-Stagni, Marco2, Author
Fujishiro, Takashi1, Author
Warkentin, Eberhard3, Author           
Meyer-Klaucke, Wolfram2, 4, Author
Ermler, Ulrich3, Author           
shima, Seigo1, 5, Author
Affiliations:
1Max‐Planck‐Institut für terrestrische Mikrobiologie, 35043 Marburg, Germany , ou_persistent22              
2EMBL Hamburg, 22603 Hamburg, Germany, ou_persistent22              
3Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068290              
4University of Paderborn, Department of Chemistry, Warburger Strasse 100, 33098 Paderborn, Germany, ou_persistent22              
5PRESTO Japan Science and Technology Agency (JST), Honcho, Kawaguchi, Saitama 332-0012, Japan, ou_persistent22              

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Free keywords: Hydrogenases; iron-guanylylpyridinol cofactor; isocyanide ligands; X-ray absorption spectroscopy; X-ray diffraction
 Abstract: Inhibition mechanism: Isocyanides strongly inhibit [Fe]-hydrogenase. X-ray crystallography and X-ray absorption spectroscopy revealed that the isocyanide binds to the trans position, versus the acyl carbon of the Fe center, and is covalently bound to the pyridinol hydroxy oxygen. These results also indicated that the hydroxy group is essential for H2 activation.

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Language(s): eng - English
 Dates: 2013-06-132013-09-032013-09-09
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201305089
 Degree: -

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Title: Angewandte Chemie, International Edition in English
  Abbreviation : Angew. Chem., Int. Ed. Engl.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 52 (37) Sequence Number: - Start / End Page: 9656 - 9659 Identifier: ISSN: 0570-0833
CoNE: https://pure.mpg.de/cone/journals/resource/0570-0833