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  Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria

Daum, B., Walter, A., Horst, A., Osiewacz, H. D., & Kühlbrandt, W. (2013). Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria. Proceedings of the National Academy of Sciences of the United States of America, 110(38), 15301-15306. doi:10.1073/pnas.1305462110.

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 Urheber:
Daum, Bertram1, Autor           
Walter, Andreas1, Autor           
Horst, Angelika1, Autor           
Osiewacz, Heinz D.2, 3, Autor
Kühlbrandt, Werner1, Autor                 
Affiliations:
1Department of Structural Biology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068291              
2Molecular Developmental Biology, Goethe University, 60438 Frankfurt am Main, Germany, ou_persistent22              
3Cluster of Excellence Frankfurt “Macromolecular Complexes,” Deutsche Forschungsgemeinschaft, 60438 Frankfurt am Main, Germany, ou_persistent22              

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Schlagwörter: subtomogram averaging; cell death
 Zusammenfassung: Aging is one of the most fundamental, yet least understood biological processes that affect all forms of eukaryotic life. Mitochondria are intimately involved in aging, but the underlying molecular mechanisms are largely unknown. Electron cryotomography of whole mitochondria from the aging model organism Podospora anserina revealed profound age-dependent changes in membrane architecture. With increasing age, the typical cristae disappear and the inner membrane vesiculates. The ATP synthase dimers that form rows at the cristae tips dissociate into monomers in inner-membrane vesicles, and the membrane curvature at the ATP synthase inverts. Dissociation of the ATP synthase dimer may involve the peptidyl prolyl isomerase cyclophilin D. Finally, the outer membrane ruptures near large contact-site complexes, releasing apoptogens into the cytoplasm. Inner-membrane vesiculation and dissociation of ATP synthase dimers would impair the ability of mitochondria to supply the cell with sufficient ATP to maintain essential cellular functions.

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Sprache(n): eng - English
 Datum: 2013-04-032013-07-222013-09-042013-09-17
 Publikationsstatus: Erschienen
 Seiten: 6
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1073/pnas.1305462110
PMID: 24006361
PMC: 3780843
 Art des Abschluß: -

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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : PNAS
  Andere : Proceedings of the National Academy of Sciences of the USA
  Kurztitel : Proc. Natl. Acad. Sci. U. S. A.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 110 (38) Artikelnummer: - Start- / Endseite: 15301 - 15306 Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230