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  Spatially asymmetric reorganization of inhibition establishes a motion-sensitive circuit

Yonehara, K., Balint, K., Noda, M., Nagel, G., Bamberg, E., & Roska, B. (2011). Spatially asymmetric reorganization of inhibition establishes a motion-sensitive circuit. Nature, 469(7330), 407-410.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-D61B-6 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-D61C-4
Genre: Zeitschriftenartikel

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 Urheber:
Yonehara, Keisuke, Autor
Balint, Kamill, Autor
Noda, Masaharu, Autor
Nagel, Georg1, Autor           
Bamberg, Ernst1, Autor           
Roska, Botond, Autor
Affiliations:
1Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_2068289              

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 Zusammenfassung: Spatial asymmetries in neural connectivity have an important role in creating basic building blocks of neuronal processing. A key circuit module of directionally selective (DS) retinal ganglion cells is a spatially asymmetric inhibitory input from starburst amacrine cells. It is not known how and when this circuit asymmetry is established during development. Here we photostimulate mouse starburst cells targeted with channelrhodopsin-2 (refs 6–8) while recording from a single genetically labelled type of DS cell. We follow the spatial distribution of synaptic strengths between starburst and DS cells during early postnatal development before these neurons can respond to a physiological light stimulus, and confirmconnectivity by monosynaptically restricted trans-synaptic rabies viral tracing. We show that asymmetry develops rapidly over a 2-day period through an intermediate state in which random or symmetric synaptic connections have been established. The development of asymmetry involves the spatially selective reorganization of inhibitory synaptic inputs. Intriguingly, the spatial distribution of excitatory synaptic inputs from starburst cells is significantly more symmetric than that of the inhibitory inputs at the end of this developmental period. Our work demonstrates a rapid developmental switch from a symmetric to asymmetric input distribution for inhibition in the neural circuit of a principal cell.

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Sprache(n): eng - English
 Datum: 2011-01-20
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 532781
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Titel: Nature
  Alternativer Titel : Nature
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 469 (7330) Artikelnummer: - Start- / Endseite: 407 - 410 Identifikator: -