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  The 2.5 Å Structure of CD1c in Complex with a Mycobacterial Lipid Reveals an Open Groove Ideally Suited for Diverse Antigen Presentation

Scharf, L., Li, N.-S., Hawk, A. J., Garzón, D., Zhang, T., Fox, L. M., et al. (2010). The 2.5 Å Structure of CD1c in Complex with a Mycobacterial Lipid Reveals an Open Groove Ideally Suited for Diverse Antigen Presentation. Immunity, 33, 853-862. doi:10.1016/j.immuni.2010.11.026.

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 Creators:
Scharf, Louise, Author
Li, Nan-Sheng, Author
Hawk, Andrew J., Author
Garzón, Diana1, Author           
Zhang, Tejia, Author
Fox, Lisa M., Author
Kazen, Allison R., Author
Shah, Sneha, Author
Haddadian, Esmael J., Author
Gumperz, Jenny E., Author
Saghatelian, Alan, Author
Faraldo-Gómez, José D.1, Author           
Affiliations:
1Max Planck Research Group of Theoretical Molecular Biophysics, Max Planck Institute of Biophysics, Max Planck Society, ou_2068295              

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 Abstract: CD1 molecules function to present lipid-based antigens to T cells. Here we present the crystal structure of CD1c at 2.5 Å resolution, in complex with the pathogenic Mycobacterium tuberculosis antigen mannosyl-b1-phosphomycoketide (MPM). CD1c accommodated MPM’s methylated alkyl chain exclusively in the A0 pocket, aided by a unique exit portal underneath the a1 helix. Most striking was an open F0 pocket architecture lacking the closed cavity structure of other CD1 molecules, reminiscent of peptide binding grooves of classical major histocompatibility complex molecules. This feature, combined with tryptophan-fluorescence quenching during loading of a dodecameric lipopeptide antigen, provides a compelling model by which both the lipid and peptide moieties of the lipopeptide are involved in CD1c presentation of lipopeptides

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Language(s): eng - English
 Dates: 2010-12
 Publication Status: Issued
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 529547
DOI: 10.1016/j.immuni.2010.11.026
 Degree: -

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Title: Immunity
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 33 Sequence Number: - Start / End Page: 853 - 862 Identifier: ISSN: 1074-7613
CoNE: https://pure.mpg.de/cone/journals/resource/954925604783