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  Molecular basis of transport and regulation in the Na+/betaine symporter BetP

Ressl, S., Terwisscha van Scheltinga, A. C., Vonrhein, C., Ott, V., & Ziegler, C. (2009). Molecular basis of transport and regulation in the Na+/betaine symporter BetP. Nature, 458(7234), 47-52. doi:10.1038/nature07819.

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Ressl, Susanne1, Autor           
Terwisscha van Scheltinga, Anke C.1, Autor           
Vonrhein, Clemens2, Autor
Ott, Vera3, Autor
Ziegler, Christine1, Autor           
Affiliations:
1Department of Structural Biology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068291              
2Global Phasing Ltd, Sheraton House, Castle Park, Cambridge CB3 0AX, UK , ou_persistent22              
3Institut für Biochemie, Universität zu Köln, 50937 Köln, Germany, ou_persistent22              

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 Zusammenfassung: Osmoregulated transporters sense intracellular osmotic pressure and respond to hyperosmotic stress by accumulation of osmolytes to restore normal hydration levels. Here we report the determination of the X-ray structure of a member of the family of betaine/choline/carnitine transporters, the Na+-coupled symporter BetP from Corynebacterium glutamicum, which is a highly effective osmoregulated uptake system for glycine betaine. Glycine betaine is bound in a tryptophan box occluded from both sides of the membrane with aromatic side chains lining the transport pathway. BetP has the same overall fold as three unrelated Na+-coupled symporters. Whereas these are crystallized in either the outward-facing or the inward-facing conformation, the BetP structure reveals a unique intermediate conformation in the Na+-coupled transport cycle. The trimeric architecture of BetP and the break in three-fold symmetry by the osmosensing C-terminal helices suggest a regulatory mechanism of Na+-coupled osmolyte transport to counteract osmotic stress.

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Sprache(n): eng - English
 Datum: 2008-07-182009-01-212009-03-05
 Publikationsstatus: Erschienen
 Seiten: 7
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/nature07819
PMID: 19262666
 Art des Abschluß: -

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Titel: Nature
  Kurztitel : Nature
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: London : Nature Publishing Group
Seiten: - Band / Heft: 458 (7234) Artikelnummer: - Start- / Endseite: 47 - 52 Identifikator: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238