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  Studies on conditional gene expression in the brain

Jerecic, J., Single, F. N., Krüth, U., Krestel, H. E., Kolhekar, R., Storck, T., et al. (1999). Studies on conditional gene expression in the brain. Annals of the New York Academy of Sciences, 868, 27-37. doi:10.1111/j.1749-6632.1999.tb11271.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-6071-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-6072-7
Genre: Journal Article
Alternative Title : Studies on conditional gene expression in the brain

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AnnNYAS_868_1999_27.pdf (Any fulltext), 700KB
 
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 Creators:
Jerecic, Jasna1, Author              
Single, Frank Nicolai1, Author              
Krüth, Ulrich1, Author              
Krestel, Heinz Eric1, Author              
Kolhekar, Rohini, Author
Storck, Thorsten, Author
Kask, Kalev, Author
Higuchi, Miyoko1, Author              
Sprengel, Rolf1, Author              
Seeburg, Peter H.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: This manuscript summarizes our recent attempts to regulate in vitro and in vivo the expression of genes encoding components and regulators of the postsynaptic machinery along with marker genes such as lacZ and GFP. In particular, we studied tTA-dependent regulation and utilized Cre in combination with reversible silencing by intron engineering of dominant negative alleles. We further present a "knockin" approach for on-site artificial regulation of chromosomal genes.

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Language(s): eng - English
 Dates: 199919991999-04-30
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Annals of the New York Academy of Sciences
  Other : Ann. N.Y. Acad. Sci.
Source Genre: Journal
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Publ. Info: New York : New York Academy of Sciences
Pages: - Volume / Issue: 868 Sequence Number: - Start / End Page: 27 - 37 Identifier: ISSN: 0077-8923
CoNE: https://pure.mpg.de/cone/journals/resource/954926958894_2