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  Interoceptive awareness changes the posterior insula functional connectivity profile

Kuehn, E., Mueller, K., Lohmann, G., & Schütz-Bosbach, S. (2016). Interoceptive awareness changes the posterior insula functional connectivity profile. Brain Structure & Function, 221(3), 1555-1571. doi:10.1007/s00429-015-0989-8.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-6DAA-E Version Permalink: http://hdl.handle.net/21.11116/0000-0004-4D32-E
Genre: Journal Article

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 Creators:
Kuehn, Esther1, Author              
Mueller, Karsten2, Author              
Lohmann, Gabriele3, Author
Schütz-Bosbach, Simone4, Author
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
3Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ou_persistent22              
4Institute of Psychology, Friedrich Alexander University Erlangen, Germany, ou_persistent22              

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Free keywords: Body awareness; Interoception; fMRI; Resting state; Functional connectivity; Plasticity
 Abstract: Interoceptive awareness describes the ability to consciously perceive inner bodily signals, such as one’s own heartbeat. The right anterior insula is assumed to mediate this ability. The role of the posterior insula, particularly posterior-to-anterior insula signal flows is less clear in this respect. We scanned 27 healthy people with either high or low interoceptive awareness using 3T fMRI, while they either monitored their own heartbeats, or external tones, respectively. We used a combination of network centrality and bivariate connectivity analyses to characterize changes in cortical signal flows between the posterior insula and the anterior insula during interoceptive awareness or exteroceptive awareness, respectively. We show that heartbeat monitoring was accompanied by reduced network centrality of the right posterior insula, and decreased functional connectivity strengths between the right posterior insula and the right mid and anterior insula. In addition, decreased signal flows between the right posterior insula and the bilateral anterior cingulate cortices, and the bilateral orbitofrontal cortices were observed during interoceptive awareness. Functional connectivity changes were only shown by people with high interoceptive awareness, and occurred specifically within the low-frequency range (i.e., <0.1 Hz). Both groups did not differ in their functional connectivity profiles during rest. Our results show for the first time that interoceptive awareness changes intra-insula signal flows in the low-frequency range. We speculate that the selective inhibition of slow signal progression along the posterior-to-anterior insula pathway during interoceptive awareness allows the salient and noiseless detection of one’s own heartbeat.

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Language(s): eng - English
 Dates: 2014-04-132015-01-072015-01-232016-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00429-015-0989-8
PMID: 25613901
Other: Epub 2015
 Degree: -

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Title: Brain Structure & Function
  Abbreviation : Brain Struct Funct
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 221 (3) Sequence Number: - Start / End Page: 1555 - 1571 Identifier: ISSN: 1863-2653
CoNE: /journals/resource/1863-2653