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  Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

Vahl, J. C., Drees, C., Heger, K., Heink, S., Fischer, J. C., Nedjic, J., et al. (2014). Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool. IMMUNITY, 41(5), 722-736. doi:10.1016/j.immuni.2014.10.012.

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 Creators:
Vahl, J. Christoph1, Author              
Drees, Christoph2, Author
Heger, Klaus1, Author              
Heink, Sylvia2, Author
Fischer, Julius C.2, Author
Nedjic, Jelena2, Author
Ohkura, Naganari2, Author
Morikawa, Hiromasa2, Author
Poeck, Hendrik2, Author
Schallenberg, Sonja2, Author
Rieß, David3, Author              
Hein, Marco Y.4, Author              
Buch, Thorsten2, Author
Polic, Bojan2, Author
Schönle, Anne2, Author
Zeiser, Robert2, Author
Schmitt-Gräff, Annette2, Author
Kretschmer, Karsten2, Author
Klein, Ludger2, Author
Korn, Thomas2, Author
Sakaguchi, Shimon2, AuthorSchmidt-Supprian, Marc1, Author               more..
Affiliations:
1Schmidt-Supprian, Marc / Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565167              
2external, ou_persistent22              
3Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              
4Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: TRANSCRIPTION FACTOR FOXP3; EPIGENETIC CHANGES; REPORTER MOUSE; EXPRESSION; DIFFERENTIATION; SPECIFICATION; STIMULATION; MECHANISMS; TOLERANCE; DISEASEImmunology;
 Abstract: Regulatory T (Treg) cells maintain immune homeostasis and prevent inflammatory and autoimmune responses. During development, thymocytes bearing a moderately self-reactive T cell receptor (TCR) can be selected to become Treg cells. Several observations suggest that also in the periphery mature Treg cells continuously receive self-reactive TCR signals. However, the importance of this inherent autoreactivity for Treg cell biology remains poorly defined. To address this open question, we genetically ablated the TCR of mature Treg cells in vivo. These experiments revealed that TCR-induced Treg lineage-defining Foxp3 expression and gene hypomethylation were uncoupled from TCR input in mature Treg cells. However, Treg cell homeostasis, cell-type-specific gene expression and suppressive function critically depend on continuous triggering of their TCR.

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Language(s): eng - English
 Dates: 2014
 Publication Status: Published in print
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: IMMUNITY
Source Genre: Journal
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Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 41 (5) Sequence Number: - Start / End Page: 722 - 736 Identifier: ISSN: 1074-7613