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  Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning

Zamanillo, D., Sprengel, R., Hvalby, Ø., Jensen, V., Burnashev, N., Rozov, A., et al. (1999). Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning. Science, 284, 1805-1811. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10364547.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-6E5B-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-6E5C-5
Genre: Journal Article
Alternative Title : Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning

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Science_284_1999_1805.pdf (Any fulltext), 670KB
 
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Zamanillo, Daniel1, Author              
Sprengel, Rolf1, Author              
Hvalby, Øivind, Author
Jensen, Vidar, Author
Burnashev, Nail2, Author              
Rozov, Andrej1, 2, Author              
Kaiser, Katharina2, Author              
Köster, Helmut Joachim2, Author              
Borchardt, Thilo1, Author              
Worley, Paul F., Author
Lübke, Joachim H. R., Author
Frotscher, Michael, Author
Kelly, Peter H., Author
Sommer, Bernd, Author
Andersen, Per, Author
Seeburg, Peter H.1, Author              
Sakmann, Bert2, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Gene-targeted mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluR-A exhibited normal development, life expectancy, and fine structure of neuronal dendrites and synapses. In hippocampal CA1 pyramidal neurons, GluR-A-/- mice showed a reduction in functional AMPA receptors, with the remaining receptors preferentially targeted to synapses. Thus, the CA1 soma-patch currents were strongly reduced, but glutamatergic synaptic currents were unaltered; and evoked dendritic and spinous Ca2+ transients, Ca2+-dependent gene activation, and hippocampal field potentials were as in the wild type. In adult GluR-A-/- mice, associative long-term potentiation (LTP) was absent in CA3 to CA1 synapses, but spatial learning in the water maze was not impaired. The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory

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Language(s): eng - English
 Dates: 1999-03-031999-05-111999-06-11
 Publication Status: Published in print
 Pages: 7
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 Rev. Type: Peer
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 284 Sequence Number: - Start / End Page: 1805 - 1811 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1