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  White matter integrity and its relationship to PTSD and childhood trauma: A systematic review and meta-analysis

Daniels, J. K., Lamke, J.-P., Gaebler, M., Walter, H., & Scheel, M. (2013). White matter integrity and its relationship to PTSD and childhood trauma: A systematic review and meta-analysis. Depression and Anxiety, 30(3), 207-216. doi:10.1002/da.22044.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-90B3-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9E70-D
Genre: Journal Article

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 Creators:
Daniels, Judith K.1, Author
Lamke, Jan-Peter1, Author
Gaebler, Michael1, Author              
Walter, Henrik1, Author
Scheel, Michael2, Author
Affiliations:
1Department Psychiatry, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department Neuroradiology, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Posttraumatic stress disorder; Childhood maltreatment; Fractional anisotropy; Diffusion tensor imaging; White matter
 Abstract: Recent reviews and meta-analyses reported structural gray matter changes in patients suffering from adult-onset posttraumatic stress disorder (PTSD) and in subjects with and without PTSD who experienced childhood trauma. However, it remains unclear if such structural changes are also affecting the white matter. The aim of this systematic review is to provide a comprehensive overview of all empirical investigations measuring white matter integrity in populations affected by PTSD and/or childhood trauma. To this end, results from different methodological approaches were included. Twenty-five articles are reviewed of which 10 pertained to pediatric PTSD and the effects of childhood trauma measured during childhood, seven to the effects of childhood trauma measured during adulthood, and eight to adult-onset PTSD. Overall, reductions in white matter volume were reported more often than increases in these populations. However, the heterogeneity of the exact locations indicates only a weak overlap across published studies. In addition, a meta-analysis was carried out on seven whole-brain diffusion tensor imaging (DTI) studies in adults. Significant clusters of both increases and decreases were identified in various structures, most notably the cingulum and the superior longitudinal fasciculus. Future research directions are discussed.

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Language(s): eng - English
 Dates: 2012-10-192012-06-162012-11-292013-01-142013-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/da.22044
BibTex Citekey: Daniels2013
PMID: 23319445
Other: Epub 2013
 Degree: -

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Title: Depression and Anxiety
  Other : Depress. Anxiety
Source Genre: Journal
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Affiliations:
Publ. Info: New York : J. Wiley
Pages: - Volume / Issue: 30 (3) Sequence Number: - Start / End Page: 207 - 216 Identifier: ISSN: 1091-4269
CoNE: /journals/resource/954927727580_1