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  Flexible adaptive paradigms for fMRI using a novel software package 'Brain Analysis in Real-Time' (BART)

Hellrung, L., Hollmann, M., Zscheyge, O., Schlumm, T., Kalberlah, C., Roggenhofer, E., et al. (2015). Flexible adaptive paradigms for fMRI using a novel software package 'Brain Analysis in Real-Time' (BART). PLoS One, 10(4): e0118890. doi:10.1371/journal.pone.0118890.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-79FC-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-78DE-D
Genre: Journal Article

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 Creators:
Hellrung, Lydia1, 2, Author              
Hollmann, Maurice1, Author              
Zscheyge, Oliver1, Author
Schlumm, Torsten3, Author              
Kalberlah, Christian1, 2, Author              
Roggenhofer, Elisabeth1, 2, 4, 5, Author              
Okon-Singer, Hadas6, Author              
Villringer, Arno1, 2, 4, 5, 7, Author              
Horstmann, Annette1, 2, 4, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              
3Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
4Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Department of Psychology, University of Haifa, Israel, ou_persistent22              
7Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: Adaptive paradigm; IAPS; Eye tracker; Software; BART
 Abstract: In this work we present a new software package offering a unified framework for the real-time adaptation of fMRI stimulation procedures. The software provides a straightforward setup and highly flexible approach to adapt fMRI paradigms while the experiment is running. The general framework comprises the inclusion of parameters from subject’s compliance, such as directing gaze to visually presented stimuli and physiological fluctuations, like blood pressure or pulse. Additionally, this approach yields possibilities to investigate complex scientific questions, for example the influence of EEG rhythms or fMRI signals results themselves. To prove the concept of this approach, we used our software in a usability example for an fMRI experiment where the presentation of emotional pictures was dependent on the subject’s gaze position. This can have a significant impact on the results. So far, if this is taken into account during fMRI data analysis, it is commonly done by the post-hoc removal of erroneous trials. Here, we propose an a priori adaptation of the paradigm during the experiment’s runtime. Our fMRI findings clearly show the benefits of an adapted paradigm in terms of statistical power and higher effect sizes in emotion-related brain regions. This can be of special interest for all experiments with low statistical power due to a limited number of subjects, a limited amount of time, costs or available data to analyze, as is the case with real-time fMRI.

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Language(s): eng - English
 Dates: 2014-01-142015-01-092015-04-02
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0118890
PMID: 25837719
PMC: PMC4383593
Other: eCollection 2015
 Degree: -

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Title: PLoS One
Source Genre: Journal
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Pages: - Volume / Issue: 10 (4) Sequence Number: e0118890 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850