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  Grey matter alterations in patients with depersonalization disorder: A voxel-based morphometry study

Daniels, J. K., Gaebler, M., Lamke, J.-P., & Walter, H. (2015). Grey matter alterations in patients with depersonalization disorder: A voxel-based morphometry study. Journal of Psychiatry & Neuroscience, 40(1), 19-27. doi:10.1503/jpn.130284.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-9025-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7989-B
Genre: Journal Article

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Daniels, Judith K.1, Author
Gaebler, Michael2, 3, 4, Author              
Lamke, Jan-Peter2, Author
Walter, Henrik2, Author
Affiliations:
1Department of Psychosomatic Medicine and Psychotherapy, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
2Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4University of Leipzig, Germany, ou_persistent22              

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 Abstract: Background To our knowledge, no whole brain investigation of morphological aberrations in dissociative disorder is available to date. Previous region-of-interest studies focused exclusively on amygdalar, hippocampal and parahippocampal grey matter volumes and did not include patients with depersonalization disorder (DPD). We therefore carried out an explorative whole brain study on structural brain aberrations in patients with DPD. Methods We acquired whole brain, structural MRI data for patients with DPD and healthy controls. Voxel-based morphometry was carried out to test for group differences, and correlations with symptom severity scores were computed for grey matter volume. Results Our study included 25 patients with DPD and 23 controls. Patients exhibited volume reductions in the right caudate, right thalamus and right cuneus as well as volume increases in the left dorsomedial prefrontal cortex and right somatosensory region that are not a direct function of anxiety or depression symptoms. Limitations To ensure ecological validity, we included patients with comorbid disorders and patients taking psychotropic medication. Conclusion The results of this first whole brain investigation of grey matter volume in patients with a dissociative disorder indentified structural alterations in regions subserving the emergence of conscious perception. It remains unknown if these alterations are best understood as risk factors for or results of the disorder.

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Language(s): eng - English
 Dates: 2013-12-122014-05-012014-10-072015-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1503/jpn.130284
PMID: 25285875
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Title: Journal of Psychiatry & Neuroscience
  Abbreviation : J Psychiatry Neurosci
Source Genre: Journal
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Pages: - Volume / Issue: 40 (1) Sequence Number: - Start / End Page: 19 - 27 Identifier: ISSN: 1180-4882
CoNE: /journals/resource/1180-4882