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  Emotion regulation and trait anxiety are predicted by the microstructure of fibers between amygdala and prefrontal cortex

Eden, A., Schreiber, J., Anwander, A., Keuper, K., Laeger, I., Zwanzger, P., et al. (2015). Emotion regulation and trait anxiety are predicted by the microstructure of fibers between amygdala and prefrontal cortex. The Journal of Neuroscience, 35(15), 6020-6027. doi:10.1523/JNEUROSCI.3659-14.2015.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-9B92-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-797B-C
Genre: Journal Article

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 Creators:
Eden, Annuschka1, Author
Schreiber, Jan2, Author              
Anwander, Alfred2, Author              
Keuper, Katharina1, 3, Author
Laeger, Inga4, Author
Zwanzger, Peter4, Author
Zwitserlood, Ienie5, Author
Kugel, Harald6, Author
Dobel, Christian1, 3, Author
Affiliations:
1Institute for Biomagnetism and Biosignal Analysis, Münster University, Germany, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              
3Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, Münster, Germany, ou_persistent22              
4Department of Psychology, Münster University, Germany, ou_persistent22              
5Münster University, Germany, ou_persistent22              
6Department of Clinical Radiology, Münster University, Germany, ou_persistent22              

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Free keywords: Amygdala; DTI; PFC; Reappraisal use; Top-down inhibition; Trait anxiety
 Abstract: Diffusion tensor imaging revealed that trait anxiety predicts the microstructural properties of a prespecified fiber tract between the amygdala and the perigenual anterior cingulate cortex. Besides this particular pathway, it is likely that other pathways are also affected. We investigated white matter differences in persons featuring an anxious or a nonanxious personality, taking into account all potential pathway connections between amygdala and anxiety-related regions of the prefrontal cortex (PFC). Diffusion-weighted images, measures of trait anxiety and of reappraisal use (an effective emotion-regulation style), were collected in 48 females. With probabilistic tractography, pathways between the amygdala and the dorsolateral PFC, dorsomedial PFC, ventromedial PFC, and orbitofrontal cortex (OFC) were delineated. The resulting network showed a direct ventral connection between amygdala and PFC and a second limbic connection following the fornix and the anterior limb of the internal capsule. Reappraisal use predicted the microstructure of pathways to all calculated PFC regions in the left hemisphere, indicating stronger pathways for persons with high reappraisal use. Trait anxiety predicted the microstructure in pathways to the ventromedial PFC and OFC, indexing weaker connections in trait-anxious persons. These effects appeared in the right hemisphere, supporting lateralization and top-down inhibition theories of emotion processing. Whereas a specific microstructure is associated with an anxious personality, a different structure subserves emotion regulation. Both are part of a broad fiber tract network between amygdala and PFC.

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Language(s): eng - English
 Dates: 2014-07-262015-02-032015-04-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.3659-14.2015
PMID: 25878275
 Degree: -

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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 35 (15) Sequence Number: - Start / End Page: 6020 - 6027 Identifier: ISSN: 0270-6474
CoNE: /journals/resource/954925502187