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  Common genetic variants influence human subcortical brain structures

Hibar, D. P., Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., et al. (2015). Common genetic variants influence human subcortical brain structures. Nature, 520, 224-229. doi:10.1038/nature14101.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-A204-2 Version Permalink: https://hdl.handle.net/21.11116/0000-0003-4A1F-9
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 Creators:
Hibar, Derrek P.1, Author
Stein, Jason L.2, Author
Renteria, Miguel E.3, Author
Arias-Vasquez, Alejandro4, 5, 6, 7, Author
Desrivières, Sylvane8, Author
Jahanshad, Neda1, Author
Toro, Roberto9, 10, 11, Author
Wittfeld, Katharina12, 13, Author
Abramovic, Lucija14, Author
Andersson, Micael15, Author
Aribisala, Benjamin S.16, 17, 18, Author
Armstrong, Nicola J.19, 20, Author
Bernard, Manon21, Author
Bohlken, Marc M.14, Author
Boks, Marco P.14, Author
Bralten, Janita4, 6, 7, Author
Brown, Andrew A.22, 23, Author
Chakravarty, M. Mallar24, 25, Author
Chen, Qiang26, Author
Ching, Christopher R. K.27, Author
Cuellar-Partida, Gabriel3, Authorden Braber, Anouk28, AuthorGiddaluru, Sudheer29, 30, AuthorGoldman, Aaron L.26, AuthorGrimm, Oliver31, AuthorGuadalupe, Tulio32, 33, Author           Hass, Johanna34, AuthorWoldehawariat, Girma35, AuthorHolmes, Avram J.36, 37, AuthorHoogman, Martine4, 7, AuthorJanowitz, Deborah13, AuthorJia, Tianye8, AuthorKim, Sungeun38, 39, 40, AuthorKlein, Marieke4, 7, AuthorKraemer, Bernd41, AuthorLee, Phil H.37, 42, 43, 44, AuthorOlde Loohuis, Loes M. 45, AuthorLuciano, Michelle46, AuthorMacare, Christine8, AuthorMather, Karen A.19, AuthorMattheisen, Manuel47, 48, 49, AuthorMilaneschi, Yuri50, AuthorNho, Kwangsik38, 39, 40, AuthorPapmeyer, Martina51, AuthorRamasamy, Adaikalavan52, 53, AuthorRisacher, Shannon L.38, 40, AuthorRoiz-Santiañez, Roberto54, 55, AuthorRose, Emma J.56, 57, AuthorSalami, Alireza15, 58, AuthorSämann, Philipp G.59, AuthorSchmaal, Lianne50, AuthorSchork, Andrew J.60, 61, AuthorShin, Jean21, AuthorStrike, Lachlan T.3, 62, 63, AuthorTeumer, Alexander64, AuthorVan Donkelaar, Marjolein M. J.4, 7, Author           Van Eijk, Kristel R.14, AuthorWalters, Raymond K.65, 66, AuthorWestlye, Lars T.23, 67, AuthorWhelan, Christopher D.1, AuthorWinkler, Anderson M.68, 69, AuthorZwiers, Marcel P.7, AuthorAlhusaini, Saud70, 71, AuthorAthanasiu, Lavinia22, 23, AuthorEhrlich, Stefan34, 37, 72, AuthorHakobjan, Marina M. H.4, 7, AuthorHartberg, Cecilie B.22, 73, AuthorHaukvik, Unn K.22, AuthorHeister, Angelien J. G. A. M.4, 7, AuthorHoehn, David59, AuthorKasperaviciute, Dalia74, 75, AuthorLiewald, David C. M.46, AuthorLopez, Lorna M.46, AuthorMakkinje, Remco R. R.4, 7, AuthorMatarin, Mar76, AuthorNaber, Marlies A. M.4, 7, AuthorMcKay, D. Reese69, 77, AuthorNeedham, Margaret56, AuthorNugent, Allison C.35, AuthorPütz, Benno59, AuthorRoyle, Natalie A.16, 18, 46, AuthorShen, Li38, 39, 40, AuthorSprooten, Emma51, 69, 77, AuthorTrabzuni, Daniah53, 78, AuthorVan der Marel, Saskia S. L.4, 7, AuthorVan Hulzen, Kimm J. E.4, 7, AuthorWalton, Esther34, AuthorWolf, Christiane59, AuthorAlmasy, Laura79, 80, AuthorAmes, David81, 82, AuthorArepalli, Sampath83, AuthorAssareh, Amelia A.19, AuthorBastin, Mark E.16, 18, 46, 84, AuthorBrodaty, Henry19, AuthorBulayeva, Kazima B.85, AuthorCarless, Melanie A.79, AuthorCichon, Sven86, 87, 88, 89, AuthorCorvin, Aiden56, AuthorCurran, Joanne E.79, AuthorCzisch, Michael59, AuthorDe Zubicaray, Greig I.62, AuthorDillman, Allissa83, AuthorDuggirala, Ravi79, AuthorDyer, Thomas D.79, 80, AuthorErk, Susanne90, AuthorFedko, Iryna O.28, AuthorFerrucci, Luigi91, AuthorForoud, Tatiana M.40, 92, AuthorFox, Peter T.80, 93, AuthorFukunaga, Masaki94, AuthorGibbs, J. Raphael53, 82, AuthorGöring, Harald H. H.79, AuthorGreen, Robert C.95, 96, AuthorGuelfi, Sebastian53, AuthorHansell, Narelle K.3, AuthorHartman, Catharina A.97, AuthorHegenscheid, Katrin98, AuthorHeinz, Andreas89, AuthorHernandez, Dena G.53, 82, AuthorHeslenfeld, Dirk J.99, AuthorHoekstra, Pieter J.97, AuthorHolsboer, Florian59, AuthorHomuth, Georg100, AuthorHottenga, Jouke-Jan28, AuthorIkeda, Masashi101, AuthorJack, Clifford R. 102, AuthorJenkinson, Mark103, AuthorJohnson, Robert104, AuthorKanai, Ryota105, 106, AuthorKeil, Maria41, AuthorKent, Jack W. 79, AuthorKochunov, Peter107, AuthorKwok, John B.108, 109, AuthorLawrie, Stephen M.51, AuthorLiu, Xinmin35, 110, AuthorLongo, Dan L.111, AuthorMcMahon, Katie L.63, AuthorMeisenzahl, Eva112, AuthorMelle, Ingrid22, 23, AuthorMohnke, Sebastian90, AuthorMontgomery, Grant W.3, AuthorMostert, Jeanette C.4, 7, AuthorMühleisen, Thomas W.87, 88, 89, AuthorNalls, Michael A.83, AuthorNichols, Thomas E.103, 113, AuthorNilsson, Lars G.15, AuthorNöthen, Markus M.87, 89, AuthorOhi, Kazutaka114, AuthorOlvera, Rene L.92, AuthorPerez-Iglesias, Rocio55, 115, AuthorPike, G. Bruce116, 117, AuthorPotkin, Steven G.118, AuthorReinvang, Ivar67, AuthorReppermund, Simone19, AuthorRietschel, Marcella31, AuthorRomanczuk-Seiferth, Nina90, AuthorRosen, Glenn D.96, 119, AuthorRujescu, Dan112, AuthorSchnell, Knut120, AuthorSchofield, Peter R.108, 109, AuthorSmith, Colin121, AuthorSteen, Vidar M.29, 30, AuthorSussmann, Jessika E.51, AuthorThalamuthu, Anbupalam19, AuthorToga, Arthur W.122, AuthorTraynor, Bryan J.83, AuthorTroncoso, Juan123, AuthorTurner, Jessica A.124, AuthorValdes Hernández, Maria C. 84, Authorvan Ent, Dennis ’t28, AuthorVan der Brug, Marcel125, AuthorVan der Wee, Nic J. A.126, AuthorVan Tol, Marie-Jose127, AuthorVeltman, Dick J.50, AuthorWassink, Thomas H.128, AuthorWestman, Eric129, AuthorZielke, Ronald H.104, AuthorZonderman, Alan B.130, AuthorAshbrook, David G.131, AuthorHager, Reinmar131, AuthorLu, Lu132, 133, 134, AuthorMcMahon, Francis J.35, AuthorMorris, Derek W.56, 135, AuthorWilliams, Robert W.132, 133, AuthorBrunner, Han G.4, 7, 136, AuthorBuckner, Randy L.37, 137, AuthorBuitelaar, Jan K.6, 7, 138, AuthorCahn, Wiepke14, AuthorCalhoun, Vince D.139, 140, AuthorCavalleri, Gianpiero L.71, AuthorCrespo-Facorro, Benedicto54, 55, AuthorDale, Anders M.141, 142, AuthorDavies, Gareth E.143, AuthorDelanty, Norman71, 144, AuthorDepondt, Chantal145, AuthorDjurovic, Srdjan22, 146, AuthorDrevets, Wayne C.35, 147, AuthorEspeseth, Thomas23, 67, AuthorGollub, Randy L.37, 72, 96, AuthorHo, Beng-Choon148, AuthorHoffmann, Wolfgang12, 64, AuthorHosten, Norbert98, AuthorKahn, René S.14, AuthorLe Hellard, Stephanie29, 30, AuthorMeyer-Lindenberg, Andreas31, AuthorMüller-Myhsok, Bertram59, 149, 150, AuthorNauck, Matthias151, AuthorNyberg, Lars15, AuthorPandolfo, Massimo145, AuthorPenninx, Brenda W. J. H.50, AuthorRoffman, Joshua L.37, AuthorSisodiya, Sanjay M.74, AuthorSmoller, Jordan W.37, 42, 43, 96, AuthorVan Bokhoven, Hans4, 7, AuthorVan Haren, Neeltje E. M.14, AuthorVölzke, Henry64, AuthorWalter, Henrik90, AuthorWeiner, Michael W.152, AuthorWen, Wei19, AuthorWhite, Tonya153, 154, AuthorAgartz, Ingrid22, 73, 155, AuthorAndreassen, Ole A.22, 23, AuthorBlangero, John79, 80, AuthorBoomsma, Dorret I.28, AuthorBrouwer, Rachel M.14, AuthorCannon, Dara M.35, 156, AuthorCookson, Mark R.83, AuthorDe Geus, Eco J. C.28, AuthorDeary, Ian J.46, AuthorDonohoe, Gary56, 135, AuthorFernández, Guillén6, 7, AuthorFisher, Simon E.7, 32, Author           Francks, Clyde7, 32, 157, Author           Glahn, David C.66, 77, AuthorGrabe, Hans J.13, 158, AuthorGruber, Oliver41, 59, AuthorHardy, John53, AuthorHashimoto, Ryota159, AuthorHulshoff Pol, Hilleke E. 14, AuthorJönsson, Erik G.22, 155, AuthorKloszewska, Iwona160, AuthorLovestone, Simon161, 162, AuthorMattay, Venkata S.26, 163, AuthorMecocci, Patrizia164, AuthorMcDonald, Colm156, AuthorMcIntosh, Andrew M.46, 51, AuthorOphoff, Roel A.14, 45, AuthorPaus, Tomas165, 166, AuthorPausova, Zdenka21, 167, AuthorRyten, Mina52, 53, AuthorSachdev, Perminder S.19, 168, AuthorSaykin, Andrew J.38, 40, 90, AuthorSimmons, Andy169, 170, 171, AuthorSingleton, Andrew83, AuthorSoininen, Hilkka172, 173, AuthorWardlaw, Joanna M.16, 18, 46, 84, AuthorWeale, Michael E.52, AuthorWeinberger, Daniel R.26, 174, AuthorAdams, Hieab H. H.154, 175, AuthorLauner, Lenore J.176, AuthorSeiler, Stephan177, AuthorSchmidt, Reinhold177, AuthorChauhan, Ganesh178, AuthorSatizabal, Claudia L.179, 180, AuthorBecker, James T.181, 182, 183, AuthorYanek, Lisa184, Authorvan der Lee, Sven J.175, AuthorEbling, Maritza72, 185, AuthorFischl, Bruce72, 185, 186, AuthorLongstreth, W. T. 187, AuthorGreve, Douglas72, 185, AuthorSchmidt, Helena188, AuthorNyquist, Paul163, AuthorVinke, Louis N.72, 185, AuthorVan Duijn, Cornelia M.175, AuthorXue, Luting189, AuthorMazoyer, Bernard190, AuthorBis, Joshua C.191, AuthorGudnason, Vilmundur192, AuthorSeshadri, Sudha179, 181, AuthorIkram, M. Arfan154, 175, AuthorThe Alzheimer’s Disease Neuroimaging Initiative, Author              The CHARGE Consortium, Author              EPIGEN, Author              IMAGEN, Author              SYS, Author              Martin, Nicholas G.3, AuthorWright, Margaret J.3, AuthorSchumann, Gunter8, AuthorFranke, Barbara4, 6, 7, AuthorThompson, Paul M. 1, AuthorMedland, Sarah E.3, Author more..
Affiliations:
1Imaging Genetics Center, Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Los Angeles, California, ou_persistent22              
2Neurogenetics Program, Department of Neurology, UCLA School of Medicine, Los Angeles, California, ou_persistent22              
3QIMR Berghofer Medical Research Institute, Brisbane, Australia, ou_persistent22              
4Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands, ou_persistent22              
5Department of Psychiatry, Radboud university medical center, Nijmegen, The Netherlands, ou_persistent22              
6Department of Cognitive Neuroscience, Radboud university medical center, Nijmegen, The Netherlands, ou_persistent22              
7Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
8MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK, ou_persistent22              
9Laboratory of Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France, ou_persistent22              
10Centre Nationale de Recherche Scientifique (CNRS) Unite´ de Recherche Associe´e (URA) 2182 Genes, Synapses and Cognition, Institut Pasteur, Paris, France, ou_persistent22              
11Université Paris Diderot, Paris, France, ou_persistent22              
12German Center for Neurodegenerative Diseases (DZNE), Greifswald, Germany, ou_persistent22              
13Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
14Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherland, ou_persistent22              
15Umea Centre for Functional Brain Imaging (UFBI), Umea University, Umea, Sweden, ou_persistent22              
16Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK, ou_persistent22              
17Department of Computer Science, Lagos State University, Lagos, Nigeria, ou_persistent22              
18Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK, ou_persistent22              
19Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia, ou_persistent22              
20School of Mathematics and Statistics, University of Sydney, Sydney, Australia, ou_persistent22              
21The Hospital for Sick Children, University of Toronto, Toronto, Canada, ou_persistent22              
22NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ou_persistent22              
23NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway, ou_persistent22              
24Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada, ou_persistent22              
25Department of Psychiatry and Biomedical Engineering, McGill University, Montreal, Canada, ou_persistent22              
26Lieber Institute for Brain Development, Baltimore, Maryland, USA, ou_persistent22              
27Interdepartmental Neuroscience Graduate Program, UCLA School of Medicine, Los Angeles, California, USA, ou_persistent22              
28Biological Psychology, Neuroscience Campus Amsterdam & EMGO Institute for Health and Care Research, VU University & VU Medical Center, Amsterdam, The Netherlands, ou_persistent22              
29NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway, ou_persistent22              
30Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway, ou_persistent22              
31Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany, ou_persistent22              
32Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
33International Max Planck Research School for Language Sciences, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL, ou_1119545              
34Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany, ou_persistent22              
35Human Genetics Branch and Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland, USA, ou_persistent22              
36Department of Psychology, Yale University, New Haven, Connecticut, USA, ou_persistent22              
37Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA, ou_persistent22              
38Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA, ou_persistent22              
39Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA, ou_persistent22              
40Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA, ou_persistent22              
41Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen, Germany, ou_persistent22              
42Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA, ou_persistent22              
43Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA, ou_persistent22              
44Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA, ou_persistent22              
45Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA, ou_persistent22              
46Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK, ou_persistent22              
47Department of Biomedicine, Aarhus University, Aarhus, Denmark, ou_persistent22              
48The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark, ou_persistent22              
49Center for integrated Sequencing, iSEQ, Aarhus University, Aarhus, Denmark, ou_persistent22              
50Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands, ou_persistent22              
51Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK, ou_persistent22              
52Department of Medical and Molecular Genetics, King’s College London, London, UK, ou_persistent22              
53Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK, ou_persistent22              
54Department of Psychiatry, University Hospital Marque´s de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain, ou_persistent22              
55Cibersam (Centro Investigación Biomédica en Red Salud Mental), Madrid, Spain, ou_persistent22              
56Neuropsychiatric Genetics Research Group and Department of Psychiatry, Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin, Ireland, ou_persistent22              
57Center for Translational Research on Adversity, Neurodevelopment and Substance Abuse (C-TRANS), Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA, ou_persistent22              
58Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden, ou_persistent22              
59Max Planck Institute of Psychiatry, Munich, Germany, ou_persistent22              
60Multimodal Imaging Laboratory, Department of Neurosciences, University of California, San Diego, California, USA, ou_persistent22              
61Department of Cognitive Sciences, University of California, San Diego, California, USA, ou_persistent22              
62School of Psychology,University of Queensland, Brisbane, Australia, ou_persistent22              
63Centre for Advanced Imaging, University of Queensland, Brisbane, Australia, ou_persistent22              
64Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
65Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA, ou_persistent22              
66Medical and Population Genetics Program, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA, ou_persistent22              
67Department of Psychology,University of Oslo, Oslo, Norway, ou_persistent22              
68The Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK, ou_persistent22              
69Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA, ou_persistent22              
70Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGillUniversity, Montreal, Canada, ou_persistent22              
71Molecular and Cellular Therapeutics, The Royal College of Surgeons, Dublin, Ireland, ou_persistent22              
72The Athinoula A.Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA, ou_persistent22              
73Department of Psychiatric Research and Development, Diakonhjemmet Hospital, Oslo, Norway, ou_persistent22              
74UCL Institute of Neurology, London, UK, ou_persistent22              
75Department of Medicine, Imperial College London, London, UK, ou_persistent22              
76Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK, ou_persistent22              
77Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut, USA, ou_persistent22              
78Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh Saudi Arabia, ou_persistent22              
79Texas Biomedical Research Institute, San Antonio, Texas, USA, ou_persistent22              
80University of Texas Health Science Center, San Antonio, Texas, USA, ou_persistent22              
81National Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Australia, ou_persistent22              
82Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia, ou_persistent22              
83Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA, ou_persistent22              
84Centre for Clinical Brain Sciences, University of Edinburgh , Edinburgh, UK, ou_persistent22              
85N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia, ou_persistent22              
86Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland, ou_persistent22              
87Institute of Human Genetics, University of Bonn, Bonn, Germany, ou_persistent22              
88Institute of Neuroscience and Medicine (INM-1), Research Centre Jühlich, Jühlich, Germany, ou_persistent22              
89Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany, ou_persistent22              
90Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany, ou_persistent22              
91Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA, ou_persistent22              
92Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA, ou_persistent22              
93South Texas Veterans Health Care System, San Antonio, Texas, USA, ou_persistent22              
94Biofunctional Imaging, Immunology Frontier Research Center, Osaka University, Osaka, Japan, ou_persistent22              
95Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA, ou_persistent22              
96Harvard Medical School, Boston, Massachusetts, USA, ou_persistent22              
97Department of Psychiatry,University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, ou_persistent22              
98Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
99Departments of Cognitive and Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands, ou_persistent22              
100Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
101Department of Psychiatiry, Touoake, Japan, ou_persistent22              
102Radiology, Mayo Clinic, Rochester, Minnesota, USA, ou_persistent22              
103FMRIB Centre, University of Oxford, Oxford, UK, ou_persistent22              
104NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, Maryland, USA, ou_persistent22              
105School of Psychology, University of Sussex, Brighton, UK, ou_persistent22              
106Institute of Cognitive Neuroscience, University College London, London, UK, ou_persistent22              
107Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Baltimore, Maryland, USA, ou_persistent22              
108Neuroscience Research Australia, Sydney, Australia, ou_persistent22              
109School of Medical Sciences, UNSW, Sydney, Australia, ou_persistent22              
110Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA, ou_persistent22              
111Lymphocyte Cell Biology Unit, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA, ou_persistent22              
112Department of Psychiatry, Ludwig-Maximilians-Universita, Munich, Germany, ou_persistent22              
113Department of Statistics & WMG, University of Warwick, Coventry, UK, ou_persistent22              
114Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan, ou_persistent22              
115Institute of Psychiatry, King’s College London, London, UK, ou_persistent22              
116Department of Neurology, University of Calgary, Calgary, Canada, ou_persistent22              
117Department of Clinical Neuroscience, University of Calgary, Calgary, Canada, ou_persistent22              
118Psychiatry and Human Behavior,University of California, Irvine, California, USA, ou_persistent22              
119Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA, ou_persistent22              
120Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany, ou_persistent22              
121Department of Neuropathology, MRC Sudden Death Brain Bank Project, University of Edinburgh, Edinburgh, UK, ou_persistent22              
122Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA, ou_persistent22              
123Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA, ou_persistent22              
124Psychology Department and Neuroscience Institute,Georgia State University, Atlanta, Georgia, USA, ou_persistent22              
125Genentech, South San Francisco, California, USA, ou_persistent22              
126Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands, ou_persistent22              
127Neuroimaging Centre, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, ou_persistent22              
128Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA, ou_persistent22              
129Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden, ou_persistent22              
130Behavioral Epidemiology Section, National Institute on Aging Intramural Research Program,, Baltimore, Maryland, USA, ou_persistent22              
131Faculty of Life Sciences, University of Manchester, Manchester, UK, ou_persistent22              
132Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, USA, ou_persistent22              
133Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, USA, ou_persistent22              
134Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, China, ou_persistent22              
135Cognitive Genetics and Therapy Group, School of Psychology & Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland, ou_persistent22              
1361Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands, ou_persistent22              
137Department of Psychology, Center for Brain Science, Harvard University, Boston, Massachusetts, USA, ou_persistent22              
138Karakter Child and Adolescent Psychiatry, Radboud university medical center, Nijmegen, The Netherlands, ou_persistent22              
139The Mind Research Network & LBERI, , Albuquerque, New Mexico, USA, ou_persistent22              
140Department of ECE, University of New Mexico, Albuquerque, New Mexico, USA, ou_persistent22              
141Center for Translational Imaging and Personalized Medicine, University of California, San Diego, California, USA, ou_persistent22              
142Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California, San Diego, California, USA, ou_persistent22              
143Avera Institute for Human Genetics , Sioux Falls, South Dakota, USA, ou_persistent22              
144Neurology Division, Beaumont Hospital, Dublin, Ireland, ou_persistent22              
145Department of Neurology, Hopital Erasme,Universite Libre de Bruxelles, Brussels, Belgium, ou_persistent22              
146Department of Medical Genetics, Oslo University Hospital, Oslo, Norway, ou_persistent22              
147Janssen Research & Development, Johnson & Johnson , Titusville, New Jersey, USA, ou_persistent22              
148Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA, ou_persistent22              
149Munich Cluster for Systems Neurology (SyNergy), Munich, Germany, ou_persistent22              
150University of Liverpool, Institute of Translational Medicine, Liverpool, UK, ou_persistent22              
151Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
152Center for Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, University of California, San Francisco, California, USA, ou_persistent22              
153Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre, Rotterdam, The Netherlands, ou_persistent22              
154Department of Radiology, Erasmus University Medical Centre, Rotterdam, The Netherlands, ou_persistent22              
155Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden, ou_persistent22              
156Clinical Neuroimaging Laboratory, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland, ou_persistent22              
157Imaging Genomics, MPI for Psycholinguistics, Max Planck Society, Wundtlaan 1, 6525 XD Nijmegen, NL, ou_2579692              
158Department of Psychiatry and Psychotherapy, HELIOS Hospital , Stralsund, Germany, ou_persistent22              
159Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan, ou_persistent22              
160Medical University of Lodz, Lodz, Poland, ou_persistent22              
161Department of Psychiatry, University of Oxford, Oxford, UK, ou_persistent22              
162NIHR Dementia Biomedical Research Unit, King’s College London, London, UK, ou_persistent22              
163Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, ou_persistent22              
164Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy, ou_persistent22              
165Research Institute, University of Toronto, Toronto, Canada, ou_persistent22              
166Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada, ou_persistent22              
167Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada, ou_persistent22              
168Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia, ou_persistent22              
169Department of Neuroimaging, Institute of Psychiatry, King’s College London, London, UK, ou_persistent22              
170Biomedical Research Centre for Mental Health, King’s College London, London, UK, ou_persistent22              
171Biomedical Research Unit for Dementia, King’s College London, London, UK, ou_persistent22              
172Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland, ou_persistent22              
173Neurocentre Neurology, Kuopio University Hospital, Kuopio, Finland, ou_persistent22              
174Departments of Psychiatry, Neurology, Neuroscience and the Institute of Genetic Medicine, Johns Hopkins University School of Medicine,, Baltimore, Maryland, USA, ou_persistent22              
175Departmen of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands, ou_persistent22              
176Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA, ou_persistent22              
177Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria, ou_persistent22              
178NSERM U897, University of Bordeaux, Bordeaux, France, ou_persistent22              
179Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA, ou_persistent22              
180Framingham Heart Study, Framingham, Massachusetts, ou_persistent22              
181Department of Neurology, School of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania, USA, ou_persistent22              
182Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA, ou_persistent22              
183Department of Psychology, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA, ou_persistent22              
184General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA, ou_persistent22              
185Department of Radiology, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts, USA, ou_persistent22              
186Computer Science and AI Lab, Massachusetts Institute of Technology, Boston, Massachusetts, USA, ou_persistent22              
187Department of Neurology University of Washington, Seattle, Washington, ou_persistent22              
188Institute of Molecular Biology and Biochemistry,Medical University Graz, Graz, Austria, ou_persistent22              
189Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA, ou_persistent22              
190Groupe d’Imagerie Neurofonctionnelle,UMR5296 CNRS, CEA and University of Bordeaux, Bordeaux, France, ou_persistent22              
191Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA, ou_persistent22              
192Icelandic Heart Association, University of Iceland, Faculty of Medicine , Reykjavik, Iceland, ou_persistent22              

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 Abstract: The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 × 10-33; 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction

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Language(s): eng - English
 Dates: 20152015
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nature14101
 Degree: -

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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 520 Sequence Number: - Start / End Page: 224 - 229 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238