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  Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila

Aso, Y., Sitaraman, D., Ichinose, T., Kaun, K. R., Vogt, K., Belliart-Guerin, G., et al. (2014). Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila. eLife, 3: e04580. doi:10.7554/eLife.04580.

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Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila.pdf
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 Creators:
Aso, Yoshinori, Author
Sitaraman, Divya, Author
Ichinose, Toshiharu1, Author           
Kaun, Karla R., Author
Vogt, Katrin1, Author           
Belliart-Guerin, Ghislain, Author
Placais, Pierre-Yves, Author
Robie, Alice A., Author
Yamagata, Nobuhiro, Author
Schnaitmann, Christopher1, Author           
Rowell, William J., Author
Johnston, Rebecca M., Author
Ngo, Teri-T B., Author
Chen, Nan, Author
Korff, Wyatt, Author
Nitabach, Michael N., Author
Heberlein, Ulrike, Author
Preat, Thomas, Author
Branson, Kristin M., Author
Tanimoto, Hiromu1, Author           
Rubin, Gerald M., Author more..
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1Max Planck Research Group: Behavioral Genetics / Tanimoto, MPI of Neurobiology, Max Planck Society, ou_1113555              

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Free keywords: LONG-TERM-MEMORY; SHORT NEUROPEPTIDE F; OLFACTORY MEMORY; CENTRAL COMPLEX; CONSOLIDATED MEMORY; NMDA RECEPTORS; TEMPERATURE PREFERENCE; GENETIC DISSECTION; MUTANT DROSOPHILA; EFFERENT NEURONS
 Abstract: Animals discriminate stimuli, learn their predictive value and use this knowledge to modify their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes. Sensory stimuli are sparsely represented by similar to 2000 Kenyon cells, which converge onto 34 output neurons (MBONs) of 21 types. We studied the role of MBONs in several associative learning tasks and in sleep regulation, revealing the extent to which information flow is segregated into distinct channels and suggesting possible roles for the multi-layered MBON network. We also show that optogenetic activation of MBONs can, depending on cell type, induce repulsion or attraction in flies. The behavioral effects of MBON perturbation are combinatorial, suggesting that the MBON ensemble collectively represents valence. We propose that local, stimulus-specific dopaminergic modulation selectively alters the balance within the MBON network for those stimuli. Our results suggest that valence encoded by the MBON ensemble biases memory-based action selection.

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Language(s): eng - English
 Dates: 2014-12-23
 Publication Status: Published in print
 Pages: 42
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000346771000009
DOI: 10.7554/eLife.04580
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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 3 Sequence Number: e04580 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X