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  Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography

Jung, Y.-J., Kang, H.-C., Choi, K.-O., Lee, S. J., Kim, D.-S., Cho, J.-H., et al. (2011). Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography. Seizure, 20(6), 449-457. doi:10.1016/j.seizure.2011.02.004.

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Jung, Young-Jin1, Author
Kang, Hoon-Chul2, Author
Choi, Keom-Ok2, Author
Lee, Soo Joon2, Author
Kim, Dong-Seok3, Author
Cho, Jae-Hyun1, Author              
Kim, Shin-Hye2, Author
Im, Chang-Hwan4, Author
Kim, Heung Dong2, Author
Affiliations:
1Department of Biomedical Engineering, Yonsei University, Wonju, Republic of Korea, ou_persistent22              
2Department of Pediatrics, Yonsei University College of Medicine, Seoul, Repulic of Korea, ou_persistent22              
3Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of Korea, ou_persistent22              
4Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea, ou_persistent22              

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Free keywords: Ictal onset zone; Lennox-Gastaut syndrome (LGS); Directional connectivity analysis; Directed transfer function (DTF); Intracranial electroencephalography (iEEG); Ictal epileptiform activity
 Abstract: Introduction Neuroscientists are becoming interested in the application of computational EEG analysis to the identification of ictal onset zones; however, most studies have focused on the localization of ictal onset zones in focal epilepsy. The present study aimed to estimate the ictal onset zone of Lennox-Gastaut syndrome (LGS) with bilaterally synchronous epileptiform discharges from intracranial electroencephalography (iEEG) recordings using directional connectivity analysis. Methods We analyzed ictal iEEG data acquired from three LGS patients who underwent epileptic surgery with favorable surgical outcomes. To identify the ictal onset zones, we estimated the functional directional connectivity network among the intracerebral electrodes using the directed transfer function (DTF) method. Results The analysis results demonstrated that areas with high average outflow values corresponded well with the surgical resection areas identified using electrophysiologic data and conventional neuroimaging modalities. Discussions Our results suggest that the DTF analysis can be a useful auxiliary tool for determining surgical resection areas prior to epilepsy surgery in LGS patients. This is the first research article demonstrating that directional connectivity analysis of iEEG recording data can be used for delineating surgical resection areas in generalized epilepsy patients who need surgical treatment.

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Language(s): eng - English
 Dates: 2011-04-232011-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.seizure.2011.02.004
 Degree: -

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Title: Seizure
Source Genre: Journal
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Publ. Info: Elsevier : Oxford, United Kingdom
Pages: - Volume / Issue: 20 (6) Sequence Number: - Start / End Page: 449 - 457 Identifier: Other: 1059-1311
CoNE: https://pure.mpg.de/cone/journals/resource/1059-1311