English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Localization of ictal onset zones in Lennox–Gastaut syndrome (LGS) based on information theoretical time delay analysis of intracranial electroencephalography (iEEG)

Cho, J.-H., Kang, H.-C., Jung, Y.-J., Lee, Y.-H., Jung, K.-Y., Kim, H. D., et al. (2012). Localization of ictal onset zones in Lennox–Gastaut syndrome (LGS) based on information theoretical time delay analysis of intracranial electroencephalography (iEEG). Epilepsy Research, 99(1-2), 78-86. doi:10.1016/j.eplepsyres.2011.10.024.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Cho, Jae-Hyun1, 2, Author              
Kang, Hoon-Chul3, Author
Jung, Young-Jin1, 4, Author
Lee, Young-Ho5, Author
Jung, Ki-Young6, Author
Kim, Heung Dong3, Author
Im, Chang-Hwan1, Author
Affiliations:
1Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea, ou_persistent22              
2Department of Biomedical Engineering, Yonsei University, Wonju, Republic of Korea, ou_persistent22              
3Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea, ou_persistent22              
4Research Institute of Industrial Science, Hanyang University, Seoul, Republic of Korea, ou_persistent22              
5Korea Research Institute of Standards and Science (KRISS), Daejeon, Republic of Korea, ou_persistent22              
6Department of Neurology, Korea University College of Medicine, Seoul, Republic of Korea, ou_persistent22              

Content

show
hide
Free keywords: Ictal onset zones; Intracranial electroencephalography (iEEG); Lennox–Gastaut syndrome (LGS); Mutual information; Secondary generalized epilepsy; Time delay estimation
 Abstract: Precise localization of ictal onset zones is of great clinical importance for successful surgery in patients with intractable drug-resistant epilepsy. Time delay analysis has been one of the most reliable and most widely used computational electroencephalogram (EEG) analysis methods for localizing ictal onset zones. However, the majority of previous studies have only been applied to the localization of ictal onset zones in focal epilepsy. In the present study, we analyzed intracranial EEG (iEEG) recordings acquired from patients with Lennox–Gaustaut syndrome (LGS), which is a type of intractable, pediatric, secondary generalized epilepsies with bilaterally synchronous ictal epileptiform discharges. To estimate the ictal onset zones from ictal iEEG recordings, we estimated time delays among iEEG signals based on the information theoretical approach. The results of the time delay analysis applied to the iEEG data of four successfully treated LGS patients corresponded well with the surgical resection areas identified by experienced epileptologists and multiple neuroimaging modalities, suggesting that the time delay analysis may provide useful information on the precise locations of ictal onset zones prior to epilepsy surgery in LGS patients.

Details

show
hide
Language(s): eng - English
 Dates: 2011-10-152011-11-082012-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.eplepsyres.2011.10.024
PMID: 22071552
Other: Epub 2011
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Epilepsy Research
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 99 (1-2) Sequence Number: - Start / End Page: 78 - 86 Identifier: ISSN: 0920-1211
CoNE: https://pure.mpg.de/cone/journals/resource/954926240466