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  Increased corticomuscular coherence in idiopathic REM sleep behavior disorder

Jung, K.-Y., Cho, J.-H., Ko, D., Seok, H. Y., Yoon, H.-K., Lee, H.-J., et al. (2012). Increased corticomuscular coherence in idiopathic REM sleep behavior disorder. Frontiers in Neurology, 3: 60. doi:10.3389/fneur.2012.00060.

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 Creators:
Jung, Ki-Young1, Author
Cho, Jae-Hyun2, 3, Author              
Ko, Deokwon1, 4, Author
Seok, Hung Youl1, Author
Yoon, Ho-Kyoung5, Author
Lee, Heon-Jeong5, Author
Kim, Leen5, Author
Im, Chang-Hwan2, Author
Affiliations:
1Department of Neurology, Korea University College of Medicine, Seoul, Republic of Korea, ou_persistent22              
2Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea, ou_persistent22              
3Department of Biomedical Engineering, Yonsei University, Wonju, Republic of Korea, ou_persistent22              
4BK21 Program for Biomedical Science, Korea University College of Medicine, Seoul, Republic of Korea, ou_persistent22              
5Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea, ou_persistent22              

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 Abstract: The authors hypothesized that if locomotor drive increases along with rapid eye movement (REM) sleep without atonia in idiopathic REM sleep behavior disorder (RBD), then RBD patients would have greater corticomuscular coherence (CMC) values during REM sleep than at other sleep stages and than in healthy control subjects during REM sleep. To explore this hypothesis, we analyzed beta frequency range CMC between sensorimotor cortex electroencephalography (EEG) and chin/limb muscle EMG in idiopathic RBD patients. Eleven drug naive idiopathic RBD patients and 11 age-matched healthy control subjects were included in the present study. All participants completed subjective sleep questionnaires and underwent polysomnography for one night. The CMC value between EEGs recorded at central electrodes and EMGs acquired at leg and chin muscles were computed and compared by repeated measures analysis of variance (ANOVA). Sleep stages and muscle (i.e., chin vs. leg) served as within-subject factors, and group served as the between-subject factor. Repeated measures ANOVA revealed no significant main effect of group (F1,20 = 0.571, p = 0.458) or muscle (F1,20 = 1.283, p = 0.271). However, sleep stage was found to have a significant main effect (F2.067,41.332 = 20.912, p < 0.001). The interaction between group and sleep stage was significant (F2.067,41.332 = 3.438, p = 0.040). RBD patients had a significantly higher CMC value than controls during REM sleep (0.047 ± 0.00 vs. 0.052 ± 0.00, respectively, p = 0.007). This study reveals increased CMC during REM sleep in patients with RBD, which indicates increased cortical locomotor drive. Furthermore, this study supports the hypothesis that sufficient locomotor drive plays a role in the pathophysiology of RBD in addition to REM sleep without atonia.

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Language(s): eng - English
 Dates: 2011-11-022012-03-282012-04-23
 Publication Status: Published online
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fneur.2012.00060
PMID: 22536195
PMC: PMC3332227
Other: eCollection 2012
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Title: Frontiers in Neurology
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 3 Sequence Number: 60 Start / End Page: - Identifier: Other: 1664-2295
CoNE: https://pure.mpg.de/cone/journals/resource/1664-2295