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Free keywords:
glycosides; macrocycles; metathesis; natural products; ruthenium
Abstract:
The reliability of ring-closing metathesis, even in complex cases, is highlighted in the first total synthesis of the structurally intriguing resin glycoside woodrosin I (1). The synthesis also shows the maturity of the trichloroacetimidate method for glycosylation and features the most advanced application of an orthoester rearrangement for the formation of a β-glycosidic bond.