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  RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress.

Saponaro, M., Mitter, R., Kantidakis, T., Kelly, G. P., Heron, M., Williams, H., et al. (2014). RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress. Cell, 157(5), 1037-1049. doi:10.1016/j.cell.2014.03.048.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-AF4E-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CCF5-2
Genre: Journal Article

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 Creators:
Saponaro, M., Author
Mitter, R., Author
Kantidakis, T., Author
Kelly, G. P., Author
Heron, M., Author
Williams, H., Author
Söding, J.1, Author              
Stewart, A., Author
Svejstrup, J. Q., Author
Affiliations:
1Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              

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 Abstract: RECQL5 is the sole member of the RECQ family of helicases associated with RNA polymerase II (RNAPII). We now show that RECQL5 is a general elongation factor that is important for preserving genome stability during transcription. Depletion or overexpression of RECQL5 results in corresponding shifts in the genome-wide RNAPII density profile. Elongation is particularly affected, with RECQL5 depletion causing a striking increase in the average rate, concurrent with increased stalling, pausing, arrest, and/or backtracking (transcription stress). RECQL5 therefore controls the movement of RNAPII across genes. Loss of RECQL5 also results in the loss or gain of genomic regions, with the breakpoints of lost regions located in genes and common fragile sites. The chromosomal breakpoints overlap with areas of elevated transcription stress, suggesting that RECQL5 suppresses such stress and its detrimental effects, and thereby prevents genome instability in the transcribed region of genes.

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Language(s): eng - English
 Dates: 2014-05-152014-05-22
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.cell.2014.03.048
 Degree: -

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Title: Cell
Source Genre: Journal
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Pages: - Volume / Issue: 157 (5) Sequence Number: - Start / End Page: 1037 - 1049 Identifier: -