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  Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

Ahmadian, M. R., Stege, P., Scheffzek, K., & Wittinghofer, A. (1997). Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nature structural biology, 4(9), 686-689. doi:10.1038/nsb0997-686.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-AF56-6 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-AF57-4
Genre: Journal Article
Alternative Title : Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

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NatStructBiol_4_1997_686.pdf (Any fulltext), 613KB
 
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http://www.nature.com/nsmb/journal/v4/n9/pdf/nsb0997-686.pdf (Any fulltext)
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 Creators:
Ahmadian, Mohammad Reza, Author
Stege, Patricia, Author
Scheffzek, Klaus1, Author           
Wittinghofer, Alfred1, Author           
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              

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 Abstract: RasGAPs supply a catalytic residue, termed the arginine finger,into the active site of Ras thereby stabilizing the transition state of the GTPase reaction and increasing the reaction rate by more than one thousand-fold, in good agreement with the structure of the Ras.RasGAP complex.

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Language(s): eng - English
 Dates: 1997-05-071997-07-141997-09-01
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666081
DOI: 10.1038/nsb0997-686
URI: http://www.ncbi.nlm.nih.gov/pubmed/9302992
Other: 5347
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Title: Nature structural biology
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Co.
Pages: - Volume / Issue: 4 (9) Sequence Number: - Start / End Page: 686 - 689 Identifier: ISSN: 1072-8368
CoNE: https://pure.mpg.de/cone/journals/resource/111073404672000