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  Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

Geyer, M., Herrmann, C., Wohlgemuth, S., Wittinghofer, A., & Kalbitzer, H. R. (1997). Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling. Nature structural biology, 4(9), 694-699. doi:10.1038/nsb0997-694.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-AF7E-E Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-AF7F-C
Genre: Journal Article
Alternative Title : Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

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NatStructBiol_4_1997_694.pdf (Any fulltext), 845KB
 
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http://www.nature.com/nsmb/journal/v4/n9/pdf/nsb0997-694.pdf (Any fulltext)
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 Creators:
Geyer, Matthias1, Author           
Herrmann, Christine, Author
Wohlgemuth, Sabine, Author
Wittinghofer, Alfred1, Author           
Kalbitzer, Hans Robert1, Author           
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              

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 Abstract: The solution structure of the Ras-binding domain (RBD) of Ral guanine-nucleotide exchange factor RalGEF was solved by NMR spectroscopy. The overall structure is similar to that of Raf-RBD, another effector of Ras, although the sequence identity is only 13%. 15N chemical shifts changes in the complex of RalGEF-RBD with Ras indicate an interaction similar to the intermolecular beta-sheet observed for the complex between Ras and Raf-RBD.

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Language(s): eng - English
 Dates: 1997-06-211997-07-181997-09
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666089
DOI: 10.1038/nsb0997-694
URI: http://www.ncbi.nlm.nih.gov/pubmed/9302994
Other: 5427
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Title: Nature structural biology
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Co.
Pages: - Volume / Issue: 4 (9) Sequence Number: - Start / End Page: 694 - 699 Identifier: ISSN: 1072-8368
CoNE: https://pure.mpg.de/cone/journals/resource/111073404672000