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  Ultrafast extraction of proteins from tissues using desorption by impulsive vibrational excitation

Kwiatkowski, M., Wurlitzer, M., Omidi, M., Ren, L., Kruber, S., Nimer, R., et al. (2015). Ultrafast extraction of proteins from tissues using desorption by impulsive vibrational excitation. Angewandte Chemie International Edition, 54(1), 285-288. doi:10.1002/anie.201407669.

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https://dx.doi.org/10.1002/anie.201407669 (Publisher version)
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 Creators:
Kwiatkowski, M.1, Author
Wurlitzer, M.1, Author
Omidi, M.1, Author
Ren, Ling2, Author              
Kruber, S.2, Author              
Nimer, R.1, Author
Robertson, W.2, Author              
Horst, A.1, Author
Miller, R. J. D.2, Author              
Schlüter, H.1, Author
Affiliations:
1University Medical Center Hamburg-Eppendorf, Department of Clinical Chemistry, Martinistraße 52, Hamburg, Germany, ou_persistent22              
2Miller Group, Atomically Resolved Dynamics Department, Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_1938288              

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Free keywords: mass spectrometry; protein extraction; proteomics; picosecond IR laser; tissue samples
 Abstract: A picosecond IR laser (PIRL) can be used to blast proteins out of tissues through desorption by impulsive excitation (DIVE) of intramolecular vibrational states of water molecules in the cell in less than a millisecond. With PIRL-DIVE proteins covering a range of a few kDa up to several MDa are extracted in high quantities compared to conventional approaches. The chemical composition of extracted proteins remains unaltered and even enzymatic activities are maintained.

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Language(s): eng - English
 Dates: 2014-07-282014-10-242015-01-02
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201407669
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem. Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH Verlag
Pages: - Volume / Issue: 54 (1) Sequence Number: - Start / End Page: 285 - 288 Identifier: Other: 1521-3773
CoNE: https://pure.mpg.de/cone/journals/resource/0570-0833