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  Prominent dendritic localization in forebrain neurons of a novel mRNA and its product, dendrin

Herb, A., Wisden, W., Catania, M. V., Marechal, D., Dresse, A., & Seeburg, P. H. (1997). Prominent dendritic localization in forebrain neurons of a novel mRNA and its product, dendrin. Molecular and Cellular Neuroscience, 8(5), 367-374. doi:10.1006/mcne.1996.0594.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B4C7-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B4C8-C
Genre: Journal Article
Alternative Title : Prominent dendritic localization in forebrain neurons of a novel mRNA and its product, dendrin

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MolCellNeurosci_8_1997_367.pdf (Any fulltext), 870KB
 
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 Creators:
Herb, Anne1, Author              
Wisden, William, Author
Catania, Maria V., Author
Marechal, Daniel, Author
Dresse, Albert, Author
Seeburg, Peter H.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: A recently cloned rat brain cDNA derives from a novel gene, termed dendrin (DEN), expressed exclusively in forebrain structures, particularly in neocortex, olfactory bulb, hippocampus, caudate-putamen, and limbic system. In these structures, the cognate mRNA is present in neuronal cell bodies and their dendrites, whereas near exclusive dendritic localization is observed for the polypeptide product. In the hippocamus, DEN mRNA is highly expressed in the cell laminae and dendritic layers of the dentate gyrus and CA1 field, but expression is markedly reduced in the CA3 and CA4 areas. The predicted primary structure of the hydrophilic, highly basic 653-amino-acid polypeptide does not suggest a function. The restricted expression and dendritic location are compatible with a role for DEN in synaptic plasticity of central neocortical forebrain neurons

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Language(s): eng - English
 Dates: 1996-10-291995-12-021997
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Molecular and Cellular Neuroscience
Source Genre: Journal
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Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 8 (5) Sequence Number: - Start / End Page: 367 - 374 Identifier: ISSN: 1044-7431
CoNE: https://pure.mpg.de/cone/journals/resource/954922650153