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  Mammalian RNA dependent deaminases and edited mRNAs

Maas, S., Melcher, T., & Seeburg, P. H. (1997). Mammalian RNA dependent deaminases and edited mRNAs. Current Opinion in Cell Biology, 9(3), 343-349. doi:10.1016/S0955-0674(97)80006-3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B4FA-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1D5C-A
Genre: Journal Article
Alternative Title : Mammalian RNA dependent deaminases and edited mRNAs

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CurrOpinCellBiol_9_1997_343.pdf (Any fulltext), 893KB
 
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 Creators:
Maas, Stefan1, Author              
Melcher, Thorsten1, Author              
Seeburg, Peter H.1, Author              
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The past year has witnessed major progress in the field of mammalian nuclear RNA editing. Two new sequence-related RNA-dependent adenosine deaminases, distantly related to the previously characterized double-stranded RNA adenosine deaminase DRADA/dsRAD, have been molecularly characterized. One of these deaminases edits in vitro with precision for the molecular determinant that controls the Ca2+ permeability of fast synaptic glutamate-gated cation channels. This deaminase, like DRADA, is expressed in many tissues and the search is now on for more substrates of these RNA-editing enzymes. Moreover, the physiological role of the apolipoprotein B RNA editing enzyme APOBEC-1 has been investigated in genetically manipulated mice

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Language(s): eng - English
 Dates: 1997
 Publication Status: Published in print
 Pages: 7
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 Table of Contents: -
 Rev. Method: Peer
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Title: Current Opinion in Cell Biology
  Other : Curr. Opin. Cell Biol.
Source Genre: Journal
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Publ. Info: Philadelphia, PA, USA : Elsevier Current Trends
Pages: - Volume / Issue: 9 (3) Sequence Number: - Start / End Page: 343 - 349 Identifier: ISSN: 0955-0674
CoNE: https://pure.mpg.de/cone/journals/resource/954925576019