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  Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance

Organisti, C., Hein, I., Grunwald Kadow, I. C., & Suzuki, T. (2015). Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance. Genes to Cells, 20(1), 50-67. doi:10.1111/gtc.12202.

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 Creators:
Organisti, Christina1, Author           
Hein, Irina1, Author           
Grunwald Kadow, Ilona C.1, Author           
Suzuki, Takashi, Author
Affiliations:
1Max Planck Research Group: Sensory Neurogenetics / Grunwald-Kadow, MPI of Neurobiology, Max Planck Society, ou_1113556              

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Free keywords: PLANAR CELL POLARITY; ABELSON TYROSINE KINASE; CENTRAL-NERVOUS-SYSTEM; LIM DOMAIN PROTEIN; TISSUE POLARITY; AXON GUIDANCE; VISUAL-SYSTEM; COMMISSURAL AXONS; NETRIN RECEPTOR; EMBRYONIC CNS
 Abstract: During central nervous system development, several guidance cues and receptors, as well as cell adhesion molecules, are required for guiding axons across the midline and along the anterior-posterior axis. In Drosophila, commissural axons sense the midline attractants Netrin A and B (Net) through Frazzled (Fra) receptors. Despite their importance, lack of Net or fra affects only some commissures, suggesting that additional molecules can fulfill this function. Recently, planar cell polarity (PCP) proteins have been implicated in midline axon guidance in both vertebrate and invertebrate systems. Here, we report that the atypical cadherin and PCP molecule Flamingo/Starry night (Fmi/Stan) acts jointly with Net/Fra signaling during midline development. Additional removal of fmi strongly increases the guidance defects in Net/fra mutants. Rescue and domain deletion experiments suggest that Fmi signaling facilitates commissural pathfinding potentially by mediating axonal fasciculation in a partly homophilic manner. Altogether, our results indicate that contact-mediated cell adhesion via Fmi acts in addition to the Net/Fra guidance system during axon pathfinding across the midline, underlining the importance of PCP molecules during vertebrates and invertebrates midline development.

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Language(s): eng - English
 Dates: 2015-01-01
 Publication Status: Issued
 Pages: 18
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000347456300005
DOI: 10.1111/gtc.12202
 Degree: -

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Title: Genes to Cells
Source Genre: Journal
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Publ. Info: Oxford, England : Blackwell Science
Pages: - Volume / Issue: 20 (1) Sequence Number: - Start / End Page: 50 - 67 Identifier: ISSN: 1356-9597
CoNE: https://pure.mpg.de/cone/journals/resource/954927741848