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  Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice

Huebbe, P., Dose, J., Schloesser, A., Campbell, G., Glüer, C.-C., Gupta, Y., et al. (2015). Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice. Molecular Nutrition & Food Research, 59(2), 334-343. doi:10.1002/mnfr.201400636.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B5F9-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B5FA-3
Genre: Journal Article

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mnfr2298.pdf (Publisher version), 2MB
 
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 Creators:
Huebbe, Patricia, Author
Dose, Janina, Author
Schloesser, Anke, Author
Campbell, Graeme, Author
Glüer, Claus-Christian, Author
Gupta, Yask, Author
Ibrahim, Saleh, Author
Minihane, Anne-Marie, Author
Baines, John F.1, Author              
Nebel, Almut, Author
Rimbach, Gerald, Author
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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Free keywords: adipose tissue; evolution and distribution of APOE alleles; lipid deposition and mobilization; mitochondrial fatty acid oxidation; skeletal muscle
 Abstract: Scope: Of the three human apolipoprotein E (APOE) alleles, the ε 3 allele is most common, which may be a result of adaptive evolution. In this study, we investigated whether the APOE genotype affects body weight and energy metabolism through regulation of fatty acid utilization. Methods and results: Targeted replacement mice expressing the human APOE3 were significantly heavier on low- and high-fat diets compared to APOE4 mice. Particularly on high-fat feeding, food intake and dietary energy yields as well as fat mass were increased in APOE3mice. Fatty acid mobilization determined as activation of adipose tissue lipase and fasting plasma nonesterified fatty acid levels were significantly lower in APOE3 than APOE4 mice. APOE4 mice, in contrast, exhibited higher expression of proteins involved in fatty acid oxidation in skeletal muscle. Conclusion: Our data suggest that APOE3 is associated with the potential to more efficiently harvest dietary energy and to deposit fat in adipose tissue, while APOE4 carriers tend to increase fatty acid mobilization and utilization as fuel substrates especially under high-fat intake. The different handling of dietary energy may have contributed to the evolution and worldwide distribution of the ε3 allele.

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Language(s): eng - English
 Dates: 2014-10-212014-09-092014-10-292014-12-122015-02
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/mnfr.201400636
 Degree: -

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Title: Molecular Nutrition & Food Research
Source Genre: Journal
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Publ. Info: Wiley-Blackwell - STM
Pages: - Volume / Issue: 59 (2) Sequence Number: - Start / End Page: 334 - 343 Identifier: ISSN: 0027-769X (print)
ISSN: 1613-4125 (print)
ISSN: 1521-3803 (online)
ISSN: 1613-4133 (online)