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  Glutamate receptor channels, RNA editing and epilepsy

Seeburg, P. H., Brusa, R., Higuchi, M., & Sprengel, R. (1997). Glutamate receptor channels, RNA editing and epilepsy. In Excitatory amino acids: from genes to therapy (Ernst Schering research foundation workshop; 23) (pp. 1-17). Heidelberg: Springer.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B735-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B736-D
Genre: Book Chapter
Alternative Title : Glutamate receptor channels, RNA editing and epilepsy

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Seeburg_1998_Excitatory Amino Acids_1.pdf (Any fulltext), 2MB
 
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 Creators:
Seeburg, Peter H.1, Author              
Brusa, Rossella1, Author              
Higuchi, Miyoko1, Author              
Sprengel, Rolf1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: In the mammalian central nervous system (CNS) fast excitatory neurotransmission is mediated by ionotropic glutamate receptors (GluRs) of the AMPA/kainate and NMDA receptor families (Collingridge and Lester 1989; Mayer and Westbrook 1987; Watkins et al. 1990). The AMPA receptors mediate the fast component of excitatory postsynaptic currents, whereas the slow component is contributed by NMDA receptors (e.g., Stern et al. 1992). The latter can be viewed as coincidence detectors of pre- and postsynaptic activity, since the gating of the integral ion channel requires two closely simultaneous events, presynaptic release of glutamate and depolarization of the postsynaptic membrane. Depolarization is induced primarily by the activation of synaptically colocalized AMPA receptors. Coincidence detection by the NMDA receptor rests on its voltage-dependent channel block by extracellular Mg2+. NMDA receptors are designed for high Ca2+ permeability, and Ca2+ influx through the NMDA receptor channel is thought to be essential for activity-dependent synaptic modulation (reviewed in Bliss and Collingridge 1993). Furthermore, excessively high Ca2+ influx through NMDA receptors has pathophysiological consequences, including epileptiform activities and neurodegeneration (Choi 1988). By contrast, Mg2+. NMDA receptors are designed for high Ca2+ permeability, and Ca2+ influx through the NMDA receptor channel is thought to be essential for activitydependent synaptic modulation (reviewed in Bliss and Collingridge 1993). Furthermore, excessively high Ca2+ influx through NMDA receptors has pathophysiological consequences, including epileptiform activities and neurodegeneration (Choi 1988)

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Language(s): eng - English
 Dates: 1997
 Publication Status: Published in print
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: Internal
 Identifiers: eDoc: 665955
Other: 5597
DOI: 10.1007/978-3-662-03596-2_1
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Title: Excitatory amino acids : from genes to therapy (Ernst Schering research foundation workshop ; 23)
Source Genre: Book
 Creator(s):
Seeburg, P. H.1, Author            
Bresink, I., Author
Turski, L., Author
Affiliations:
1 Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704            
Publ. Info: Heidelberg : Springer
Pages: - Volume / Issue: 23 Sequence Number: - Start / End Page: 1 - 17 Identifier: ISBN: 978-3-662-03598-6
ISBN: 978-3-662-03596-2