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  Tissue specific control regions of the N-methyl-D-aspartate receptor subunit NR2C promotorsubunit NR2C promotor

Suchanek, B., Seeburg, P. H., & Sprengel, R. (1997). Tissue specific control regions of the N-methyl-D-aspartate receptor subunit NR2C promotorsubunit NR2C promotor. Biological Chemistry, 378, 929-934. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9377491.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B746-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B747-7
Genre: Journal Article
Alternative Title : Tissue specific control regions of the N-methyl-D-aspartate receptor subunit NR2C promotor

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BiologChem_378_1997_929.pdf (Any fulltext), 17MB
 
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 Creators:
Suchanek, Bettina1, Author              
Seeburg, Peter H.1, Author              
Sprengel, Rolf1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: Cerebellar granule cells / Neuron-specific expression / Promoter region / Silencing
 Abstract: In the mouse brain, the N-methyl-D-aspartate receptor subunit NR2C (e-3) is mainly detected in the cerebellar granule cells starting from the second week of postnatal life. In order to improve our understanding of molecular mechanisms of this neuron-specific, spatial and temporal gene expression, different promoter fragments were used to control indicator genes in nondifferentiated rat pheochromocytoma (PC12) cells, in human embryonal kidney (HEK293) cells and in transgenic mice. A 400 bp NR2C promoter region upstream of the transcriptional start site was identified as a basal promoter that was negatively regulated possibly by a neuron restrictive silencer element (NRSE) that is localized 664 base pairs downstream from the tanscriptional start sites

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Language(s): eng - English
 Dates: 1997-05-061997-09-101997-08-01
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 666396
URI: http://www.ncbi.nlm.nih.gov/pubmed/9377491
Other: 4636
 Degree: -

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Title: Biological Chemistry
  Other : Biological Chemistry Hoppe-Seyler (Berlin)
  Abbreviation : Biol Chem Hoppe Seyler
Source Genre: Journal
 Creator(s):
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Publ. Info: Berlin : W. de Gruyter
Pages: - Volume / Issue: 378 Sequence Number: - Start / End Page: 929 - 934 Identifier: Other: 1437-4315
ISSN: 1431-6730
CoNE: https://pure.mpg.de/cone/journals/resource/954927622123