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  Identifying enantiomers in mixtures of chiral molecules with broadband microwave spectroscopy

Shubert, V. A., Schmitz, D., Patterson, D., Doyle, J. M., & Schnell, M. (2014). Identifying enantiomers in mixtures of chiral molecules with broadband microwave spectroscopy. Angewandte Chemie International Edition, 53(4), 1152-1155. doi:10.1002/anie.201306271.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-BE65-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-E2A0-1
Genre: Journal Article

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https://dx.doi.org/10.1002/anie.201306271 (Publisher version)
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 Creators:
Shubert, V. Alvin1, 2, Author              
Schmitz, David1, 2, 3, Author              
Patterson, David, Author
Doyle, John M., Author
Schnell, Melanie1, 2, Author              
Affiliations:
1Structure and Dynamics of Cold and Controlled Molecules, Independent Research Groups, Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_1938292              
2Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany, ou_persistent22              
3International Max Planck Research School for Ultrafast Imaging & Structural Dynamics (IMPRS-UFAST), Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_2266714              

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Free keywords: absolute configuration; chiral mixtures; chirality; enantiomer identification; microwave spectroscopy
 Abstract: Chirality-sensitive broadband microwave spectroscopy was performed on mixtures of carvone enantiomers and conformers to distinguish enantiomers, measure enantiomeric excesses, and determine the absolute configurations of the enantiomers. This method uses microwave three-wave mixing and is inherently well-suited to the analysis of mixtures - a unique advantage over other techniques. In contrast to conventional microwave spectroscopy, the phase of the received signal is also exploited. This phase depends upon the signs of the molecules' dipole-moment components and is used to identify the excess enantiomer. The measured signal amplitude determines the size of the excess. The broadband capabilities of the spectrometer were used to simultaneously excite and measure two conformers of carvone, demonstrating the analysis of a sample with multiple chiral species. Employing quantum chemical calculations and the measured phases, the absolute configurations of the enantiomers are determined. Enantiomer differentiation, enantiomeric excess measurement, and absolute configuration determination within a mixture of gas-phase chiral molecules are demonstrated. In these experiments, microwave three-wave mixing within supersonic jets is combined with chirped-pulse broadband microwave spectroscopy. This new technique is now a significant step closer to broader application.

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Language(s): eng - English
 Dates: 2013-07-182013-12-062014-01-20
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/anie.201306271
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem. Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH Verlag
Pages: - Volume / Issue: 53 (4) Sequence Number: - Start / End Page: 1152 - 1155 Identifier: Other: 1521-3773
CoNE: /journals/resource/0570-0833