English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse

Geiger, J. R. P., Lübke, J. H. R., Roth, A., Frotscher, M., & Jonas, P. (1997). Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron, 18(6), 1009-1023. doi:10.1016/S0896-6273(00)80339-6.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse

Files

show Files
hide Files
:
Neuron_18_1997_1009.pdf (Any fulltext), 452KB
 
File Permalink:
-
Name:
Neuron_18_1997_1009.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Geiger, Jörg R. P., Author
Lübke, Joachim H. R., Author
Roth, Arnd1, Author              
Frotscher, Michael, Author
Jonas, Peter1, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

Content

show
hide
Free keywords: -
 Abstract: Glutamatergic transmission at a principal neuron-interneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis. Evoked EPSPs with rapid time course (half duration = 4 ms; 34 degrees C) were generated at multiple synaptic contacts established on the interneuron dendrites close to the soma. The underlying postsynaptic conductance change showed a submillisecond rise and decay, due to the precise timing of glutamate release and the rapid deactivation of the postsynaptic AMPA receptors. Simulations based on a compartmental model of the interneuron indicated that the rapid postsynaptic conductance change determines the shape and the somatodendritic integration of EPSPs, thus enabling interneurons to detect synchronous principal neuron activity.

Details

show
hide
Language(s): eng - English
 Dates: 1997-05-011997-04-101997-05-011997-06-01
 Publication Status: Published in print
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuron
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 18 (6) Sequence Number: - Start / End Page: 1009 - 1023 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565