Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
 Lokale TagsFreigabegeschichteDetailsÜbersicht
  Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons

Schiller, J., Schiller, Y., Stuart, G., & Sakmann, B. (1997). Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons. The Journal of Physiology - London, 505(3), 605-616. doi:10.1111/j.1469-7793.1997.605ba.x.

Item is

 

einblenden: alle ausblenden: alle

Basisdaten

einblenden: ausblenden:
Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-C6A5-D Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-1F3A-8
Genre: Zeitschriftenartikel
Alternativer Titel : Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons

Dateien

einblenden: Dateien
ausblenden: Dateien
:
JPhysiol_505_1997_605.pdf (beliebiger Volltext), 3MB
 
Datei-Permalink:
-
Name:
JPhysiol_505_1997_605.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Eingeschränkt (Max Planck Institute for Medical Research, MHMF; )
MIME-Typ / Prüfsumme:
application/pdf
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:
ausblenden:
externe Referenz:
http://onlinelibrary.wiley.com/doi/10.1111/j.1469-7793.1997.605ba.x/epdf (beliebiger Volltext)
Beschreibung:
-
OA-Status:
externe Referenz:
http://dx.doi.org/10.1111/j.1469-7793.1997.605ba.x (beliebiger Volltext)
Beschreibung:
-
OA-Status:

Urheber

einblenden:
ausblenden:
 Urheber:
Schiller, Jackie1, Autor           
Schiller, Yitzhak1, Autor           
Stuart, Greg1, Autor           
Sakmann, Bert1, Autor           
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: 1. Simultaneous whole-cell voltage and Ca2+ fluorescence measurements were made from the distal apical dendrites and the soma of thick tufted pyramidal neurons in layer 5 of 4-week-old (P28-32) rat neocortex slices to investigate whether activation of distal synaptic inputs can initiate regenerative responses in dendrites. 2. Dual whole-cell voltage recordings from the distal apical trunk and primary tuft branches (540-940 microns distal to the soma) showed that distal synaptic stimulation (upper layer 2) evoking a subthreshold depolarization at the soma could initiate regenerative potentials in distal branches of the apical tuft which were either graded or all-or-none. These regenerative potentials did not propagate actively to the soma and axon. 3. Calcium fluorescence measurements along the apical dendrites indicated that the regenerative potentials were associated with a transient increase in the concentration of intracellular free calcium ([Ca2+]i) restricted to distal dendrites. 4. Cadmium added to the bath solution blocked both the all-or-more dendritic regenerative potentials and local dendritic [Ca2+]i transients evoked by distal dendritic current injection. Thus, the regenerative potentials in distal dendrites represent local Ca2+ action potentials. 5. Initiation of distal Ca2+ action potentials by a synaptic stimulus required coactivation of AMPA- and NMDA-type glutamate receptor channels. 6. It is concluded that in neocortical layer 5 pyramidal neurons of P28-32 animals glutamatergic synaptic inputs to the distal apical dendrites can be amplified via local Ca2+ action potentials which do not reach threshold for axonal AP initiation. As amplification of distal excitatory synaptic input is associated with a localized increase in [Ca2+]i these Ca2+ action potentials could control the synaptic efficacy of the distal cortico-cortical inputs to layer 5 pyramidal neurons

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 1997-04-101997-08-141997-12-15
 Publikationsstatus: Erschienen
 Seiten: 12
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 664961
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160039/
URI: http://onlinelibrary.wiley.com/doi/10.1111/j.1469-7793.1997.605ba.x/full
Anderer: 7130
DOI: 10.1111/j.1469-7793.1997.605ba.x
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: The Journal of Physiology - London
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London : Cambridge University Press
Seiten: - Band / Heft: 505 (3) Artikelnummer: - Start- / Endseite: 605 - 616 Identifikator: ISSN: 0022-3751
CoNE: https://pure.mpg.de/cone/journals/resource/954925334693_2