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  Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons

Schiller, J., Schiller, Y., Stuart, G., & Sakmann, B. (1997). Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons. The Journal of Physiology - London, 505(3), 605-616. doi:10.1111/j.1469-7793.1997.605ba.x.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-C6A5-D Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-1F3A-8
Genre: Journal Article
Alternative Title : Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons

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 Creators:
Schiller, Jackie1, Author           
Schiller, Yitzhak1, Author           
Stuart, Greg1, Author           
Sakmann, Bert1, Author           
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: 1. Simultaneous whole-cell voltage and Ca2+ fluorescence measurements were made from the distal apical dendrites and the soma of thick tufted pyramidal neurons in layer 5 of 4-week-old (P28-32) rat neocortex slices to investigate whether activation of distal synaptic inputs can initiate regenerative responses in dendrites. 2. Dual whole-cell voltage recordings from the distal apical trunk and primary tuft branches (540-940 microns distal to the soma) showed that distal synaptic stimulation (upper layer 2) evoking a subthreshold depolarization at the soma could initiate regenerative potentials in distal branches of the apical tuft which were either graded or all-or-none. These regenerative potentials did not propagate actively to the soma and axon. 3. Calcium fluorescence measurements along the apical dendrites indicated that the regenerative potentials were associated with a transient increase in the concentration of intracellular free calcium ([Ca2+]i) restricted to distal dendrites. 4. Cadmium added to the bath solution blocked both the all-or-more dendritic regenerative potentials and local dendritic [Ca2+]i transients evoked by distal dendritic current injection. Thus, the regenerative potentials in distal dendrites represent local Ca2+ action potentials. 5. Initiation of distal Ca2+ action potentials by a synaptic stimulus required coactivation of AMPA- and NMDA-type glutamate receptor channels. 6. It is concluded that in neocortical layer 5 pyramidal neurons of P28-32 animals glutamatergic synaptic inputs to the distal apical dendrites can be amplified via local Ca2+ action potentials which do not reach threshold for axonal AP initiation. As amplification of distal excitatory synaptic input is associated with a localized increase in [Ca2+]i these Ca2+ action potentials could control the synaptic efficacy of the distal cortico-cortical inputs to layer 5 pyramidal neurons

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Language(s): eng - English
 Dates: 1997-04-101997-08-141997-12-15
 Publication Status: Issued
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664961
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160039/
URI: http://onlinelibrary.wiley.com/doi/10.1111/j.1469-7793.1997.605ba.x/full
Other: 7130
DOI: 10.1111/j.1469-7793.1997.605ba.x
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Title: The Journal of Physiology - London
Source Genre: Journal
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Publ. Info: London : Cambridge University Press
Pages: - Volume / Issue: 505 (3) Sequence Number: - Start / End Page: 605 - 616 Identifier: ISSN: 0022-3751
CoNE: https://pure.mpg.de/cone/journals/resource/954925334693_2